Mechanism of anesthetic action studied by interfacial vibrational spectroscopy

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Adsorption behavior of sodium stearate molecules at fused quartz/solution interface was studied by measuring SFG spectra in sodium stearate aqueous solution, followed by under Ar gas, in pure water, and under Ar gas flow again. Strong peaks due to CH stretching of CH3 group appeared under Ar gas flow, showing the presence of the stearic acid monolayer with very high conformational order. However, no SFG signal was detected when it was contact with water, showing that the structure of stearic acid monolayer was totally disordered in water. It was also found that the well ordered stearic acid monolayer was formed only below critical micelle concentration (CMC).The effect of trehalose on the stability of DMPC bilayer in dry state was also studied by SFG and AFM measurements. It was found that trehalose was effective for stabilizing DMPC bilayer in dry state. Results showed that trehalose was effective for stabilizing DMPC bilayer domain in dry state.