Detection of trace amount of toxic heavy metal ions in environmental and biological samples with highly sensitive and specific fluorescent probes

针对特定金属离子的高灵敏度、细胞渗透性荧光探针已经开发出来。在我们的探针设计中，金属结合位点和荧光片段结合在一个分子中。合成的重金属靶向荧光探针在细胞外和细胞内条件下进行了评价。通过对配体支架的精心设计，已经开发出几种对锌、镉和汞具有特异性反应的荧光探针。本研究结果为未来荧光探针的设计提供了一个重要的路线图。

Highly sensitive, cell-permeable fluorescent probes for specific metal ions have been developed. In our probe design, metal binding site and fluorescent moiety are combined in a molecule. The synthesized heavy metal targeted fluorescent probe was evaluated extra- and intracellular conditions.By careful design of the ligand scaffolds, several fluorescent probes that exhibit specific response for zinc, cadmium, and mercury have been developed. The present results provide an important roadmap for designing future fluorescent probes.