Detection of trace amount of toxic heavy metal ions in environmental and biological samples with highly sensitive and specific fluorescent probes

已经开发出用于特定金属离子的高灵敏度、细胞可渗透的荧光探针。在我们的探针设计中，金属结合位点和荧光部分结合在一个分子中。对合成的重金属靶向荧光探针进行了细胞外和细胞内条件的评价，通过精心设计配体支架，开发了几种对锌、镉和汞具有特异性响应的荧光探针。目前的研究结果为设计未来的荧光探针提供了重要的路线图。

Highly sensitive, cell-permeable fluorescent probes for specific metal ions have been developed. In our probe design, metal binding site and fluorescent moiety are combined in a molecule. The synthesized heavy metal targeted fluorescent probe was evaluated extra- and intracellular conditions.By careful design of the ligand scaffolds, several fluorescent probes that exhibit specific response for zinc, cadmium, and mercury have been developed. The present results provide an important roadmap for designing future fluorescent probes.