Roles for neural crest derivatives in retaining motor neuron cell bodies in the fish embryonic spinal cord.

我们发现表达tag1的神经嵴细胞（NCCs）在阻止斑马鱼胚胎脊髓运动神经元迁移中起重要作用。Tag1缺失导致NCC沿轴突排列破坏，NCC细胞死亡，雪旺细胞减少。这些胚胎显示运动神经元胞体脱位出脊髓。结果表明，功能雪旺细胞的分化需要tag1介导的NCC和运动轴突之间的相互作用，并且NCC衍生物保持胚胎脊髓完整性的类似功能在脊椎动物中是保守的。

We showed Tag1-expressing neural crest cells (NCCs) play an important role to prevent motor neuron emigration from the embryonic spinal cord in Zebrafish. Tag1 deficiency causes disruption of NCC alignment along axon, cell death of NCC, and Schwann cell reduction. Such embryos show the dislocation of motor neuron cell body out of the spinal cord. The results show that the Tag1-mediated interaction between NCC and motor axon is required for the differentiation of functional Schwann cells, and that comparable function of NCC derivatives to retain the integrity of embryonic spinal cord is conserved among vertebrates.