The elucidation of oxidation mechanism of a DNA base and search of the highly bioavailable antioxidants

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The oxidative formation of 8-oxo-guanosine in DNA is closely associated with the induction of degenerative diseases, including cancer. However, its endogenous oxidant is unclear. The present study showed that the endogenous oxidant was lipid hydroperoxides generating in biomembrane such as mitochondrial membrane, but was not hydrogen peroxide that had been recognized conventionally. Also, the study found that lipid-soluble antioxidants were able to suppress the formation of 8-oxo-guanosine. Thus, vegetables, fruits and tea including the lipid-soluble antioxidants such as xanthophyll astaxanthin and catechol flavonoids, quercetin and liteorin, can prevent form degenerative diseases.