Novel anti-infection Drug-delivery strategy by using ovotransferrin and its domains

结果表明，卵转铁蛋白（OTf）结合不同的不溶性磺胺类抗生素和复合物中，这些疏水抗生素成为完全水溶性。该抗菌复合物对几种病原体或革兰氏阳性或革兰氏阴性菌株显示出有效的抗菌活性。引人注目的是，复合物能够到达并杀死感染人结肠细胞（HCT-116）的细胞内病原体，并且发现该机制是通过人细胞表面发现的转移受体通过内吞介导的。这一发现预示着OTf作为药物载体在感染性疾病治疗中的潜在应用前景。

The results demonstrate that ovotransferrin (OTf) binds different insoluble sulfa antibiotics and for complex in which these hydrophobic antibiotics become totally water soluble. The antibiotics-off complexes showed potent antimicrobial activity against several pathogens or either Gram-positive or Gram-negative strains. Strikingly, the complexes were able to reach and kill pathogens intracellularly infecting human colon cells (HCT-116), and the mechanism was found to be mediated through endocytosis via transferring receptor found at the surface of human cells. The finding herald a fascinating opportunity with potential application of OTf as drug carrier for the treatment of infectious diseases.