Chiral Drug Delivery Systems to Tackle Cancerous Chirality

材料科学领域塑造了人类历史的年龄与药物输送系统带来了控制的，时间敏感的药物释放机制的开始。手性是自然物质普遍存在的性质，也是药物的基本理化特性。在药物传递系统（DDS）中，这方面迄今为止被忽视，但为了开发高效和特异性的系统，必须考虑手性。该项目致力于设计和开发针对癌细胞独特的肿瘤性手性和拓扑变化的新型手性DDS。为了设计这些系统，需要探索和表征健康细胞和癌细胞的手性和拓扑结构，包括肿瘤形成过程。DDS的合成将解决肿瘤特异性手性靶点以及癌细胞的独特拓扑结构。利用聚（乳酸-共乙醇酸）和聚甘油-聚蓖麻油酸共聚物的微尺寸结构，或使用Ti（IV）基配合物获得金属络合物体系，可以将癌细胞作为一个整体靶向。纳米级的递送系统将在非手性聚合物骨架中加入手性分子，控制整体的手性。总体而言，该项目旨在设计和制造开创性的手性给药系统，以实现卓越的靶向性和特异性，从而实现安全有效的给药。

Material science field has shaped the history of humankind for ages with drug delivery systems bringing the inception of controlled, time sensitive release mechanism of pharmaceuticals. Chirality is a ubiquitous property of natural matter and was also introduced as an essential physiochemical trait of drugs. In drug delivery systems (DDS) this aspect was overlooked so far but to develop highly efficient and specific systems, chirality must be considered. The proposed project strives to design and develop novel chiral DDS targeting the neoplastic chiral and topological changes uniquely exhibited by cancer cells. To design these systems, chirality and topology of healthy and cancer cells need to be explored and characterized, including the tumour formation process. Synthesis of DDS will address the tumour specific chiral targets as well as the unique topology of the cancer cells. Targeting cancer cells as a whole would be achieved using poly(lactic-co-glycolic acid) and polyglycerol polyricinoleate copolymers micro sized structures, or using Ti(IV) based complexes to obtain metallohelical systems. Nano- size delivery systems will incorporate chiral molecules within achiral polymer backbone, controlling the overall handedness. Overall, the proposed project aspires to design and fabricate pioneering chiral delivery systems to achieve superior targeting and specificity to achieve safe and efficient drug administration.