Chiral Drug Delivery Systems to Tackle Cancerous Chirality

应对癌症手性的手性药物输送系统

• 批准号: EP/X027236/1
• 负责人: Maya Miller
• 金额: $ 26万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX027236%2F1
• 关键词: Chiral; Drug; Delivery; Systems; Tackle

Material science field has shaped the history of humankind for ages with drug delivery systems bringing the inception of controlled, time sensitive release mechanism of pharmaceuticals. Chirality is a ubiquitous property of natural matter and was also introduced as an essential physiochemical trait of drugs. In drug delivery systems (DDS) this aspect was overlooked so far but to develop highly efficient and specific systems, chirality must be considered. The proposed project strives to design and develop novel chiral DDS targeting the neoplastic chiral and topological changes uniquely exhibited by cancer cells. To design these systems, chirality and topology of healthy and cancer cells need to be explored and characterized, including the tumour formation process. Synthesis of DDS will address the tumour specific chiral targets as well as the unique topology of the cancer cells. Targeting cancer cells as a whole would be achieved using poly(lactic-co-glycolic acid) and polyglycerol polyricinoleate copolymers micro sized structures, or using Ti(IV) based complexes to obtain metallohelical systems. Nano- size delivery systems will incorporate chiral molecules within achiral polymer backbone, controlling the overall handedness. Overall, the proposed project aspires to design and fabricate pioneering chiral delivery systems to achieve superior targeting and specificity to achieve safe and efficient drug administration.

材料科学领域已经塑造了人类的历史与药物输送系统带来了可控的，时间敏感的药物释放机制的开始。手性是天然物质普遍存在的性质，也被认为是药物的基本理化特性。在药物传递系统（DDS）中，这方面迄今被忽视，但要开发高效和特异性系统，必须考虑手性。该项目致力于设计和开发新型手性DDS，针对癌细胞特有的肿瘤手性和拓扑变化。为了设计这些系统，需要探索和表征健康和癌细胞的手性和拓扑结构，包括肿瘤形成过程。DDS的合成将针对肿瘤特异性手性靶点以及癌细胞的独特拓扑结构。使用聚（乳酸-共-乙醇酸）和聚甘油聚蓖麻醇酸酯共聚物微尺寸结构，或使用基于Ti（IV）的络合物以获得金属螺旋系统，将实现靶向癌细胞作为整体。纳米尺寸的传递系统将在非手性聚合物骨架内引入手性分子，从而控制整体手性。总的来说，拟议的项目渴望设计和制造开创性的手性传递系统，以实现上级靶向和特异性，实现安全和有效的药物管理。