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Chemical and biological studies on the functions of propolis

Chemical and biological studies on the functions of propolis
蜂胶功能的化学和生物学研究
批准号:
23580180
负责人:
KUMAZAWA Shigenori
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
Propolis is a natural resinous substance collected by honeybees from buds and exudates of certain trees and plants to protect their beehive from enemies. It is used as folk medicine in many regions of the world. In this study, chemical and biological methods were applied to evaluate the functions of propolis. In particular, chemical analyses of the propolis from Jeju (Korea) and the Solomon Islands were carried out, and we determined several new compounds from them. In addition, we searched for antiangiogenic compounds from propolis, the ethanol extracts of Okinawan propolis showed significant antiangiogenic activities in vitro and in vivo assay systems, and we evaluated the modes of action of antiangiogenic effects of the major component of Okinawan propolis, nymphaeol-A by investigating the inhibition of tube formation, as well as changes in survival signals and apoptotic pathways using human umbilical vein endothelial cells.
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DOI: --
发表时间: 2013
期刊: Food Science and Technology Research
影响因子: 0.6
作者: [Su Jin Choi, Kohsuke Shimomura, Shigenori Kumazawa, Mok-Ryeon Ahn]
通讯作者: Mok-Ryeon Ahn
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Saori Inui, Takahiro Hosoya, Yuko Shimamura, Shuichi Masuda, Kenichi Shirafuji, Reuben Toli Moli, Shigenori Kumazawa]
通讯作者: Shigenori Kumazawa
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [乾 沙王里,島村裕子,増田修一,白藤謙一,Reuben T Moli, 熊澤茂則]
通讯作者: 熊澤茂則
ブラジル産プロポリスに含まれる2種の桂皮酸誘導体は、異なる機構を介してアディポネクチンの発現低下を抑制する
巴西蜂胶中含有的两种肉桂酸衍生物通过不同的机制抑制脂联素表达的下降。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [栗田真衣, ら(7名), 高橋 恭子, 池田理恵,柳沢政由,高橋信之,河田照雄,熊澤茂則,山乙教之,中込泉,広野修一,津田孝範]
通讯作者: 池田理恵,柳沢政由,高橋信之,河田照雄,熊澤茂則,山乙教之,中込泉,広野修一,津田孝範
29
    Studies on the honeybee products as functional foods
    • 批准号:
      18580126
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.6万
    • 财政年份:
      2006
    • 负责人:
      KUMAZAWA Shigenori
    • 依托单位:
    Chemical and biological studies of propolis and its origin plants
    • 批准号:
      15580111
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      2003
    • 负责人:
      KUMAZAWA Shigenori
    • 依托单位:
    海外基金