Metabolic conversion of dietary xanthophylls and their actions on oxidative stress induced by light irradiation

膳食叶黄素的代谢转化及其对光照射诱导的氧化应激的作用

• 批准号: 23580189
• 负责人: NAGAO Akihiko
• 金额: $ 3.33万
• 依托单位: National Agriculture and Food Research Organization
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580189/
• 关键词: キサントフィル; ルテイン; ゼアキサンチン; β－クリプトキサンチン; 酸化的代謝; NO産生; 光酸化安定性; 抗炎症; 抗酸化性; 立体配置; 哺乳類

Oxidative metabolism of dietary xanthophylls was elucidated by analyzing the metabolic activity of mouse liver. The 3-hydroxy beta-end group of xanthophylls was converted to 3-oxo epsilon-end group, via an intermediate having 3-oxo beta-end group, which was produced by dehydrogenation dependent on a coenzyme NAD. This metabolic reaction might be involved in eliminating xanthophylls from the tissues, because of the intermediate was extremely unstable. Stability of carotenoids accumulated in cultured cells exposed to blue-light irradiation was found to be quite different among carotenoids with diverse structures.

通过对小鼠肝脏代谢活性的分析，阐明了饲料中叶黄素的氧化代谢。叶黄素的3-羟基-端基通过辅酶NAD脱氢产生具有3-氧-端基的中间体转化为3-氧- epsilon-端基。这种代谢反应可能涉及从组织中消除叶黄素，因为中间体非常不稳定。在蓝光照射下，不同结构的细胞积累的类胡萝卜素的稳定性有很大差异。

项目成果

ゼアキサンチンとβ-クリプトキサンチンの酸化的代謝産物

玉米黄质和β-隐黄质的氧化代谢物

• 发表时间: 2013
• 作者: 長尾昭彦;眞岡孝至;小林みゆき;小竹英一;小野祐嗣
• 通讯作者: 小野祐嗣

Oxidative metabolism of dietary xanthophylls and their implications for bioavailability and function

膳食叶黄素的氧化代谢及其对生物利用度和功能的影响

• 发表时间: 2014
• 作者: 太田敏郎;熊澤茂則他;Akihiko Nagao
• 通讯作者: Akihiko Nagao

ルテインに対するマウス肝臓の代謝活性

小鼠肝脏对叶黄素的代谢活性

• 发表时间: 2012
• 作者: 長尾昭彦;眞岡孝至;小竹英一;小野祐嗣;亀山眞由美
• 通讯作者: 亀山眞由美