Mass production of 15N labeled DNJ to evaluate the absorption and excretion of 1-deoxynojirimycin

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Mulberry leaves have the unique ingredient called 1-deoxynojirimycin which suppresses the postprandial blood glucose, so that are considered as the food materials which are expected to prevent diabetes. Sufficient safety assessment of DNJ is necessary to be widely accepted as the functional food material in the market. In this research, we tried to clarify the absorption, distribution, metabolism and excretion of DNJ. We established the mass production method of DNJ by using fermentation technique, followed by succeed to produce 10g of the purified 15N labeled DNJ. We orally administrated the purified 15N labeled DNJ to rats, now studying the mechanism analysis and safety evaluation.