Identification of lesions responsible for fatal outcome in rats infected with Borna disease virus

点击翻译按钮获取中文摘要

Newborn rats were inoculated intracranially with CRNP5 variant of Borna disease virus (BDV) with severe pathogenesis, CRP3 BDV variant with mild pathogenesis, and nine recombinant BDV (rBDV) variants and examined for 8 weeks. 1. The CRNP5 had the highest score for incidence and severity of Borna disease (BD). Four groups of rBDV variants had a higher score than CRP3. 2. The body weight increase of four rBDV variants was lower than that of other rBDV variants and CRP3 from day 20 after inoculation. 3. All BDV inoculated brains were positive for anti BDV antibodies immunohistochemically. The virus titer for pup fatalities was significantly higher than that of pups on termination. 4. Four rBDV variants including L1(L1417R) mutation had higher scores for the severity of perivascular cuffing of mononuclear cells and L1(L1417R) may play an important role for the pathogenicity of BD. 5. Menigoencephalitis was observed only in rBDV variants. The pup fatalities had higher scores.