Establishment of novel and objective ultrasonographic examination and its application to clinical veterinary medicine

为建立一种新颖、客观的超声检查方法，并将其应用于兽医临床，本研究采用Sonazoid声学造影剂，对正常犬胰腺血流灌注的基本参数进行了测定。在此基础上，通过对犬急性胰腺炎模型的超声造影分析，建立了以胰腺血流灌注变化为核心的急性胰腺炎诊断新标准，并应用二维斑点追踪超声心动图结合时间-左房面积曲线分析评价了健康犬左房相位功能。所获得的测量结果的重复性和再现性是足够的。这一结果表明，需要研究来确定犬患者的临床适用性。

To establish novel and objective ultrasonographic examination and apply it to clinical veterinary medicine, fundamental parameters of normal canine pancreatic perfusion were determined by using contrast agent Sonazoid. Then, novel diagnostic critetria for acute pancreatitis focused on pancreatic perfusion changes was established based on analysis of contrast-enhanced ultrasonographic examination in experimentally induced acute pancreatitis model in the dog.In addition, left atrial phasic function in healthy dogs by means of 2-D speckle tracking echocardiography with time-left atrial area curve analysis was evaluated. The repeatability and reproducibility of obtained measurements were adequate. This results indicates that studies are needed to determine clinical applicability in canine patients.