Development of targeting liposomal drugs using functional coating a folate-polymer conjugate

点击翻译按钮获取中文摘要

The tumor targeting of anticancer drugs is important in chemotherapy to reduce serious side-effect for patients. Folate-polymer-coated liposomes were developed for targeted chemotherapy using doxorubicin (DXR) as a model drug. Folate-poly(L-lysine) (F-PLL) conjugates were synthesized. DXR-loaded anionic liposomes were coated with F-PLL, using Layer-by layer method. In KB cells overexpressing folate receptors, F-PLL-coated liposomal DXR increased the cellular association and cytotoxicity compared with that of PLL-coated liposomes. Differently in folate-PEG modified liposome, higher folate conjugated PLL-coated liposome showed higher KB cellular uptake, suggesting different distribution of folate at the surface of liposomes.Folate-targeted liposomes were prepared successfully by coating the folate-polymer-conjugate F-PLL.