Evaluation of nasal absorption enhancer using rheological characteristic of nasal mucus

利用鼻粘液流变特性评价鼻腔吸收促进剂

• 批准号: 08672488
• 负责人: MAITANI Yoshie
• 金额: $ 0.9万
• 依托单位: Hoshi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672488/
• 关键词: nasal absorption; nasal mucosa; absorption enhancer; excipient; mucus; rheometer; レオロジー; 鼻汁; 弾性率

The enhancers are needed to increase the absorption of drug through the nasal mucosa, but were reported to alter nasal morphology. The one of tactics to develop the nasal absorption is to affect the nasal mucus, not nasal mucosa. Nasal absorption enhancer was evaluated by the change of rheological characteristic in nasal mucus using rheometer and viscometer. The nasal mucus of rabbits, insulin for drug, and carbopol, hydroxypropylcellulose, carboxymethylcellulose, avicell, bile salts and soybean-derived sterol and sterylglucoside mixture for enhancer were used. The nasal absorption enhancer is quantitatively evaluated using the rheological characteristic in nasal mucus. The results exibited that the enhancer that decreased rheological parameters, affected nasal mucosa morphologically. This method is useful to divide absorption enhancers to affect nasal mucus and mucosae and to develop the safe enhancers.

需要增强剂来增加药物通过鼻粘膜的吸收，但据报道会改变鼻形态。促进鼻腔吸收的策略之一是影响鼻粘液，而不是鼻粘膜。用流变仪和粘度计测定鼻粘膜流变学特性，评价鼻吸收促进剂的作用。以兔鼻粘液为原料，以胰岛素为药物，卡波姆、羟丙基纤维素、羧甲基纤维素、微晶纤维素、胆盐、大豆甾醇和甾醇葡萄糖苷混合物为促进剂。使用鼻粘液中的流变学特性定量评价鼻吸收促进剂。结果表明，增强剂降低了鼻粘膜的流变学参数，对鼻粘膜的形态学有影响。该方法有助于筛选鼻粘膜吸收促进剂的作用机制，开发安全的鼻粘膜吸收促进剂。

项目成果

米谷 芳枝: "大豆由来ステロールおよびそのグルコシド混合物含有リポソームの薬物担体に関する研究" 薬学雑誌. 116・12. 901-910 (1996)

Yoshie Yonetani：“含有大豆甾醇及其糖苷混合物的脂质体的药物载体的研究”医药杂志116・12（1996）。

Y.Maitani: "In vitro nasal transport across rabbit mucosa : effect of oxygen bubbling, pH and hypertonic pressure on permeability of lucifer yellow, diazepam and 17 β-estradiol." Int.J.Pharm.146. 11-19 (1997)

Y.Maitani：“通过兔粘膜的体外鼻转运：氧气鼓泡、pH 和高渗压对荧光黄、地西泮和 17 β-雌二醇的渗透性的影响。” Int.J.Pharm.11-19 (1997)。

Y.Maitani: "Design of ocular/lacrimal and nasal systems through analysis of drug administration and absorption" J.Contr.Release. 49. 185-192 (1997)

Y.Maitani：“通过分析药物给药和吸收来设计眼/泪道和鼻系统”J.Contr.Release。

Y.Maitani: "Design of ocular/lacrimal and nasal systems through analysis of drug administration and absorption" J.Contr.Release.49(2,3). 185-192 (1997)

Y.Maitani：“通过分析药物给药和吸收来设计眼/泪道和鼻系统”J.Contr.Release.49(2,3)。

米谷 芳枝: "大豆由来ステロール及びそのグルコシド混合物含有リポソームの薬物担体としての性質とその応用" 星薬科大学紀要. 38. 19-27 (1996)

Yoshie Yonetani：“含有大豆甾醇及其糖苷混合物的脂质体作为药物载体的特性及其应用”，《星药科大学通报》，38. 19-27 (1996)。