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Studies on regulation of neutrophilic airway inflammation in severe asthma and chronic obstructive pulmonary disease (COPD)

重度哮喘和慢性阻塞性肺疾病（COPD）中性粒细胞气道炎症调节的研究

基本信息

批准号：
23590093
负责人：
NABE Takeshi
金额：
$ 3.33万
依托单位：
Kyoto Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

Neutrophilic airway inflammation, a characteristic feature of severe asthma and chronic obstructive pulmonary disease (COPD), was analyzed using murine models, and regulation of the neutrophilic inflammation was evaluated. Unexpectedly, a good COPD model could not be developed even when cigarette smoke was co-administered with an infection factor to mice for a long term. On the other hand, in a murine model of severe asthma, neutrophils were involved in airway obstruction induced several hours after exposure to allergen. It was also found that macrophage-derived chemokines were involved in the neutrophilic airway inflammation. In addition, the neutrophilic inflammation was suppressed by an anti-inflammatory molecule, interleukin (IL)-10, which was endogenously produced. Next, development of a new cellular immunotherapy for asthma was started: Method for induction of IL-10-producing T lymphocytes from spleen cells was developed in vitro.

用小鼠模型分析重症哮喘和慢性阻塞性肺疾病(COPD)的特征--中性粒细胞炎症，并评价其调节作用。令人意想不到的是，即使长期将香烟烟雾与感染因子联合给予小鼠，也无法建立良好的COPD模型。另一方面，在严重哮喘的小鼠模型中，中性粒细胞参与了暴露于变应原数小时后引起的呼吸道阻塞。还发现巨噬细胞衍生的趋化因子参与了中性粒细胞的气道炎症。此外，中性粒细胞炎症被内源性产生的抗炎分子白介素10抑制。接下来，开始了一种治疗哮喘的新的细胞免疫疗法的开发：体外诱导脾细胞产生IL-10的T淋巴细胞的方法。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Editorial, Possible antigen-specific cellular immunotherapy using Tr1 cells for atopic diseases

社论，使用 Tr1 细胞治疗特应性疾病的可能抗原特异性细胞免疫疗法

DOI：
发表时间：
2012
期刊：
Biochem & Pharmacol
影响因子：
0
作者：
中村瑞穂;坂本明彦;照井祐介;富取秀行;斎木遼太郎;吉田　円;五十嵐一衛;柏木敬子;Takeshi Nabe
通讯作者：
Takeshi Nabe

Editorial, Tumor necrosis factor alpha-mediated asthma?

社论，肿瘤坏死因子α介导的哮喘？

DOI：
10.1159/000342420
发表时间：
2013
期刊：
Int. Arch. Allergy Immunol
影响因子：
0
作者：
Yang Cao;Masanori Fujii;Keiichi Ishihara;Satoshi Akiba;Hiroyuki Yasui;Takeshi Nabe;Takeshi Nabe
通讯作者：
Takeshi Nabe

Nobuaki Mizutani, Takeshi Nabe, and Shin Yoshino: Exposure to multiwalled carbon nanotubes and allergen promotes early- and late-phase increases in airway resistance in mice.

Nobuaki Mizutani、Takeshi Nabe 和 Shin Yoshino：暴露于多壁碳纳米管和过敏原会促进小鼠气道阻力的早期和晚期增加。