Pathophysiological significance of sialic acid in CNS

唾液酸在中枢神经系统中的病理生理意义

• 批准号: 23590108
• 负责人: HISATSUNE Akinori
• 金额: $ 3.33万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590108/
• 关键词: シアル酸; 神経細胞; ミクログリア; 中枢神経系; シアリダーゼ; 炎症

Sialic acid is increased in serum and spinal fluid of CNS disease patients. Therefore to examine effects of sialic acid in pathophysiological situation, following are examined: 1) An effect of sialic acid on a function of microglia was performed. Desialylation on microglia induced significant expressions of inflammatory cytokines. 2) An effect of sialic acid on function of neuron was performed. Desialylation on neuron required for significant neurite outgrowth by neurite inducers. 3) An effect of desialylation in the brain was performed. Desialylation induced significant microglial activation and neuronal loss, indicating that desialylation induced neuronal damage which might be correlated with CNS disease.

中枢神经系统疾病患者的血清和脊髓液中唾液酸增加。因此，为了检查唾液酸在病理生理状况中的影响，进行了以下检查：1）唾液酸对小胶质细胞功能的作用。小胶质细胞上的脱酰基诱导炎症细胞因子的显着表达。 2）唾液酸对神经元功能的影响。神经元诱导剂的明显神经突生长所需的神经元脱酰化。 3）在大脑中进行脱酰化的作用。脱酰化诱导了显着的小胶质激活和神经元丧失，表明脱扬型诱导的神经元损伤可能与中枢神经系统疾病相关。

项目成果

Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress

下丘脑切片培养物中的食欲素神经元容易受到内质网应激的影响

• 发表时间: 2011
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Michinaga S;Hisatsune A;Isohama Y;Katsuki H
• 通讯作者: Katsuki H

Therapeutic Effect of Nicotine in a Mouse Model of Intracerebral Hemorrhage

• DOI: 10.1124/jpet.111.182519
• 发表时间: 2011-09-01
• 期刊: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
• 影响因子: 3.5
• 作者: Hijioka, Masanori;Matsushita, Hideaki;Katsuki, Hiroshi
• 通讯作者: Katsuki, Hiroshi

Involvement of bacterial sialidase in the development of bacterial meningitis

细菌唾液酸酶参与细菌性脑膜炎的发展

• 发表时间: 2011
• 作者: Akinori Hisatsune;Takashi Kasada;Shuhei Takahashi;Yoichiro Isohama;Hiroshi Katsuki
• 通讯作者: Hiroshi Katsuki

Endogenous retinoid signaling after intracerebral hemorrhage in mice

小鼠脑出血后的内源性类维生素A信号传导

• 发表时间: 2014
• 作者: 松下英明;肱岡雅宣;石橋勇人;阿南順平;倉内祐樹;久恒昭哲;関貴弘;首藤紘一;香月博志
• 通讯作者: 香月博志

Mechanisms of retinoid-induced nNOS upregulation and neurite elongation in SH-SY5Y cells

类维生素A诱导SH-SY5Y细胞中nNOS上调和神经突伸长的机制

• 发表时间: 2013
• 作者: Tatsuya Fujibayashi;Yuki Kurauchi;Akinori Hisatsune;Yoichiro Isohama;Hiroshi Katsuki
• 通讯作者: Hiroshi Katsuki