Protein tyrosine phosphorylation in the neurovascular unit in cerebrovascular disease and therapeutic strategies

点击翻译按钮获取中文摘要

This study sought to determine the role of protein tyrosine phosphorylation in the neurovascular unit after stroke. This study demonstrated that MPO-positive cells were increased in the surrounding brain capillaries after stroke, suggesting neutrophil infiltration. This infiltration was inhibited by src inhibitor. The increases in the levels of NOX subunit p67phox and COX-2 were also attenuated by src inhibitor. In addition, this study suggests that the pathophysiological alteration of the blood brain barrier after stroke may be regulated by tyrosine phosphorylation of PDGFR-beta in the pericytes.