Study of roles of endogenous hydrogen sulfide in stomach with mucosal injury

在人胃癌来源的AGS细胞中，我们的研究结果表明，由哺乳动物体内形成H2S的酶之一半胱硫氨酸- γ -裂解酶（CSE）产生的内源性硫化氢（H2S）加速了AGS细胞的增殖。H2S的作用可能部分是通过内源性H2S激活NF-kappaB，从而增加Cav3.2 t型钙通道的功能，上调抗凋亡蛋白Bcl-2和Bcl-xL。这些途径有望成为胃癌治疗的有效靶点。

In human gastric cancer-derived AGS cells, our findings suggest that endogenous hydrogen sulfide (H2S) produced by cystathionine-gamma-lyase (CSE), one of H2S-forming enzymes in the mammalian body, accelerates the proliferation of AGS cells. The effects of H2S may be mediated, in part, by increase in function of Cav3.2 T-type calcium channels and upregulation of anti-apoptotic proteins, Bcl-2 and Bcl-xL, via activation of NF-kappaB caused by endogenous H2S. These pathways can be expected to be effective targets for treatment of gastric cancer.