Study on effects of Helicobacter pylori infection on expression and function of proteinase-activated receptors in gastric mucosal epithelium.

在胃癌患者胃黏膜上皮癌区，我们发现蛋白酶激活受体-1 （PAR1）的表达与幽门螺杆菌（h.p ylori）感染水平呈正相关，提示PAR1的表达增加参与了幽门螺杆菌相关性胃癌的发展。我们还确定了幽门螺杆菌是否在各种细胞系中具有par活化蛋白酶。然而，我们在幽门螺杆菌提取物中没有发现任何激活PAR1、PAR2或PAR4的蛋白酶。

In the cancer area of gastric mucosal epithelium from gastric cancer patients, we found a tendency that expression of proteinase-activated receptor-1 (PAR1) was positively correlated with infection levels of Helicobacter pylori (H. pylori), suggesting involvement of increased expression of PAR1 in the development of H. pylori-related gastric cancer. We also determined if H. pylori might possess PAR-activating proteinases in various cell lines. However, we did not find any proteinases that activate PAR1, PAR2 or PAR4, in the H. pylori extracts.