Establishment of the disinfection technique with hydroxyl radicals and catalase inhibitor based on the reaction kinetic analysis

点击翻译按钮获取中文摘要

Disinfection treatment with photolysis of hydrogen peroxide could be a novel alternative to existing antibiotics because the risk of inducing bacterial resistance by the disinfection treatment was proven to be quite low. In addition, we revealed that bactericidal activity of photo-irradiated hydrogen peroxide was synergistically augmented in the presence of polyphenol containing-herbal medicines and -plant extracts. The bactericidal activity of the disinfection treatment is due to hydroxyl radicals generated by photolysis of hydrogen peroxide which disappear immediately after the cessation of photo-irradiation. Therefore, there would be no problematic issues on residual toxicity, and there would be an advantage that antioxidant activity of the herbal medicines and plant extracts would alleviate the oxidative damage that might be caused by hydroxyl radicals during photo-irradiation.