Regionalization of the axial skeleton derived from the somites: its ontogenesis and phylogenesis

来自体节的轴向骨骼的区域化：其本体发生和系统发育

• 批准号: 23590219
• 负责人: AOYAMA Hirohiko
• 金额: $ 3.33万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590219/
• 关键词: 形態形成; 軸骨格; 体節; 側板; 肋骨; 接触阻止; ニワトリ; 進化; 部域特異性; ニワトリ胚; マウス胚; 軟骨形成; 骨化; 側板中胚葉; 表皮外胚葉; Wnt; 細胞移動; 部域化; 体節中胚葉; 組織間相互作用; マウス; 比較発生学

In the axial skeleton of mammals and birds, the ribs are exclusively in the thoracic region. The most part of the rib is consisuted of the distal rib, which develops depending on the surface ectoderm. Regionalization of the axial skeleton is, thus, considered to be differential development of the distal rib according to its location. An ectopic transplantation of the thoracic somite into the lumbosacral region in a 2-day chick embryo caused ectopic rib, which was shorter than the normal rib. In the course of development of this chimera, we found that the thoracic somite cells stopped their migration when they met the lumbosacral lateral plate mesoderm.On the other hand, we compared the axial skeleton development between chick embryos and mouse embryos and found that order of the ossification was different, which coincide with an idea that the regionalization of the axial skeleton independently occurs in the course of phylogenesis of mammals and birds.

在哺乳动物和鸟类的轴向骨骼中，肋骨仅在胸部区域。 肋骨的大部分是由远端肋骨确定的，该肋骨取决于表面外胚层。 因此，根据其位置，轴向骨骼的区域化被认为是远端肋骨的差异发育。 在为期2天的小鸡胚胎中，胸腔体向腰ac区的异位移植引起异位肋，比正常肋骨短。 In the course of development of this chimera, we found that the thoracic somite cells stopped their migration when they met the lumbosacral lateral plate mesoderm.On the other hand, we compared the axial skeleton development between chick embryos and mouse embryos and found that order of the ossification was different, which coincide with an idea that the regionalization of the axial skeleton independently occurs in the course of phylogenesis of mammals and birds.

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