Possible Involvement of ion Channels in atrial fibrillation

对瞬时受体电位(Trp)通道的研究极大地扩展了我们对心肌细胞内钙信号分子基础的认识。心脏色氨酸通道的功能意义可能与膜电位的改变或钙离子进入非收缩房室有关，在那里诱导了与各种心脏疾病相关的基因表达。这项研究强调了TRP通道在心脏病中的预期作用的某些方面。有证据表明：(A)TRPC1、TRPC3或TRPC6的活性增加参与了心肌肥厚的发生，这些TRPC通道对多种肥厚刺激起着独特的感受器作用；(B)TRPM4、7和TRPC3、6的活性增加参与了心房重构或机械牵张对心律失常的影响。最终，Trp通道可能成为治疗人类心脏病的新的药理靶点。

Studies of transient receptor potential (TRP) channels have significantly extended our knowledge regarding the molecular basis of Ca2+ signals in cardiac myocytes. The functional significance of cardiac TRP channels is likely connected to the alteration of membrane potential or Ca2+ entry into a noncontractile compartment, where gene expression responsible for various cardiac diseases is induced. This study highlights some aspects of TRP channels with anticipated roles in cardiac disease. Evidence suggests that (a) increased activities of TRPC1, TRPC3, or TRPC6 are involved in the development of cardiac hypertrophy, where these TRPC channels act as unique sensors for a wide range of hypertrophic stimuli, and (b) increased activities of TRPM4,7 and TRPC3,6 are involved in atrial remodeling or mechanical stretch on cardiac arrhythmia. Ultimately, TRP channels may become novel pharmacological targets in the treatment of human cardiac disease.