Possible Involvement of ion Channels in atrial fibrillation

离子通道可能参与心房颤动

• 批准号: 23590256
• 负责人: IINO Kenji
• 金额: $ 3.33万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590256/
• 关键词: 心房細動; イオンチャネル; TRPチャネル; ＴＲＰチャネル

Studies of transient receptor potential (TRP) channels have significantly extended our knowledge regarding the molecular basis of Ca2+ signals in cardiac myocytes. The functional significance of cardiac TRP channels is likely connected to the alteration of membrane potential or Ca2+ entry into a noncontractile compartment, where gene expression responsible for various cardiac diseases is induced. This study highlights some aspects of TRP channels with anticipated roles in cardiac disease. Evidence suggests that (a) increased activities of TRPC1, TRPC3, or TRPC6 are involved in the development of cardiac hypertrophy, where these TRPC channels act as unique sensors for a wide range of hypertrophic stimuli, and (b) increased activities of TRPM4,7 and TRPC3,6 are involved in atrial remodeling or mechanical stretch on cardiac arrhythmia. Ultimately, TRP channels may become novel pharmacological targets in the treatment of human cardiac disease.

瞬时受体电位（TRP）通道的研究，显着扩展了我们的知识，关于心肌细胞中的Ca 2+信号的分子基础。心脏TRP通道的功能意义可能与膜电位的改变或Ca2+进入非收缩室有关，在非收缩室中诱导引起各种心脏疾病的基因表达。这项研究强调了TRP通道在心脏疾病中预期作用的一些方面。有证据表明，（a）TRPC 1、TRPC 3或TRPC 6的活性增加参与心脏肥大的发展，其中这些TRPC通道作为广泛的肥大刺激的独特传感器，和（B）TRPM 4，7和TRPC 3，6的活性增加参与心房重构或心律失常的机械牵张。最终，TRP通道可能成为治疗人类心脏疾病的新的药理学靶点。

项目成果

Possible involvement of TRP channels in cardiac hypertrophy and arrhythmia Curent Topics

TRP 通道可能参与心脏肥大和心律失常

• 发表时间: 2013
• 期刊: Medical Chemistry
• 作者: Watanabe H;Iino K;Ohba T;Ito H
• 通讯作者: Ito H

Sildenafil prevents the up-regulation of TRPCs in the development of cardiomyocytes hypertrophy

西地那非可防止心肌细胞肥大发展过程中 TRPC 的上调

• 发表时间: 2013
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Kiso H;Ohba T;Iino K;Terada Y;Murakami M;Ono K;Watanabe H;Ito H
• 通讯作者: Ito H

TRP channel and cardiac hypertrophy

TRP通道与心脏肥大

• 发表时间: 2013
• 作者: Watanabe H;Iino K;Ohba T;Ito H;Watanabe H
• 通讯作者: Watanabe H

Transient receptor potential(TRP) Channel and Hypertensive Heart Disease

瞬时受体电位（TRP）通道与高血压心脏病

• 作者: Hiroyuki Watanabe;Hiroshi Ito;Watanabe H
• 通讯作者: Watanabe H

Possible involvement of TRP channels in cardiac hypertrophy and arrhythmia.

• DOI: 10.2174/1568026611313030006
• 发表时间: 2013-01
• 期刊: Current topics in medicinal chemistry
• 影响因子: 3.4
• 作者: Hiroyuki Watanabe;K. Iino;T. Ohba;Hiroshi Ito