Role of AMP kinase in cellular proliferation and polarity in the gastrointestinal tract

AMPK是瘦素受体信号传导的关键分子，不仅是调节全身代谢能量平衡的重要因子，而且影响细胞增殖。然而，瘦素在胃肠道中的病理生理作用尚不清楚。我们展示了AMPK磷酸化与高脂肪饮食喂养引起的萎缩性胃炎进展的相关性。由于组织结构破坏和代谢能改变是致癌性特征之一，可以想象AMPK磷酸化在萎缩性胃炎进展中的作用。

AMPK, a critical molecule in leptin receptor signaling is not only an essential factor for regulation of metabolic energy balance at the whole-body level but also affects cellular proliferation.However, it remains unknown the pathophysiological role of leptin in gastrointestinal tract. We show the relevance of AMPK phosphorylation for the progression of atrophic gastritis due to a high-fat diet feeding. SInce destruction of tissue construction and metabolic energy alteration is one of oncogenic feature, it is conceivable that the effect of AMPK phosphorylation on progression of atrophic gastritis.