Ion Channels Related to Cell Excitability of GnRH Neurons

本研究旨在确定与大鼠GnRH神经元兴奋性密切相关的离子通道。首先，我们分析了K通道，发现生长抑素受体（Sst），SK通道和Kv 7通道的参与。SK和Kv 7参与后超极化的产生。第二，在寡细胞RT-PCR中分析阳离子通道。GnRH神经元表达Na泄漏通道（Nalcn）、Nalc相关蛋白Unc-80和超极化激活的核苷酸门控阳离子通道HCN，这些离子通道可能决定了GnRH神经元的兴奋性。

This study aimed to determine ion channels which closely related to the excitability of rat GnRH neurons. First, we analyzed K channels and found an involvement of somatostatin receptors (Sst), SK channels,and Kv7 channels. SK and Kv7 are involved in the generation of afterhyperpolarization. Second, cationic channels were analyzed in oligo-cell RT-PCR. GnRH neurons express Nalcn (Na leak channel), Unc-80 (associate protein to Nalc), and HCN (Hyperpolarization-activated cNucleotide gated Cationic channels).These ion channels may determine the cell excitability of GnRH neurons.