Analysis of M2 macrophage/cancer interaction in carcinogenesis, growth and progression of human esophageal squamous cell carcinoma

M2巨噬细胞/癌症相互作用在人食管鳞状细胞癌发生、生长和进展中的分析

• 批准号: 23590397
• 负责人: YOKOZAKI Hiroshi
• 金额: $ 3.33万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590397/
• 关键词: 病理学; 癌; 食道; マクロファージ; 癌・間質相互作用

Infiltration of M2 type macrophage in human esophageal squamous cell carcinomas (ESCCs) was associated with grade of malignancy and patients prognosis. Cyr61, extracted as one of the up-regulated genes during M2 differentiation of THP-1 human monocytic leukemia cell line by conditioned media of ESCC cell lines, induced expression of CD204 and migration of macrophages through activation of MEK/Erk signal pathways. GDF15, from activated human peripheral blood monocyte derived macrophage, promoted growth of ESCC cells by activating Akt and Erk. Activated macrophages promoted the growth of immortalized normal human esophageal squamous epithelial cells.

M2型巨噬细胞在食管鳞状细胞癌中的浸润与食管癌的恶性程度及患者的预后有关。Cyr 61是在人单核细胞白血病细胞系THP-1经食管鳞癌细胞系条件培养基诱导分化为M2期时表达上调的基因之一，它通过激活MEK/Erk信号通路诱导CD 204表达和巨噬细胞迁移。GDF 15来源于活化的人外周血单核细胞来源的巨噬细胞，通过激活Akt和Erk促进ESCC细胞的生长。活化的巨噬细胞促进永生化的正常人食管鳞状上皮细胞的生长。

项目成果

Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells.

• DOI: 10.1038/sj.bjc.6605309
• 发表时间: 2009-10-20
• 期刊: British journal of cancer
• 影响因子: 8.8

Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells

• DOI: 10.1159/000325538
• 发表时间: 2011-01-01
• 期刊: PATHOBIOLOGY
• 影响因子: 5
• 作者: Hashimoto, Okito;Shimizu, Kazuya;Hori, Yuichi
• 通讯作者: Hori, Yuichi

食道扁平上皮癌におけるCD204陽性マクロファージの役割

CD204阳性巨噬细胞在食管鳞状细胞癌中的作用

• 发表时间: 2013
• 作者: 重岡学;高瀬信尚;西尾真理;裏川直樹;宇都宮壮顕;綿島健人;狛雄一朗;仙波秀峰;横崎宏
• 通讯作者: 横崎宏

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Clinicopathological characteristics of abnormal micro-lesions at the oro-hypopharynx detected by a magnifying narrow band imaging system

窄带放大成像系统检测口咽部异常微病变的临床病理特征

• DOI: 10.1111/j.1443-1661.2011.01177.x
• 发表时间: 2012
• 期刊: Dig Endosc
• 作者: Tanaka S;Morita Y;Fujita T;Yokozaki H;Obata D;Fujiwara S;Wakahara C;Masuda A;Sugimoto M;Sanuki T;Yoshida M;Toyonaga T;Kutsumi H;Azuma T
• 通讯作者: Azuma T