The role of Mastermind in B-cell lymphoma

Mastermind 在 B 细胞淋巴瘤中的作用

基本信息

批准号：
23590413
负责人：
HIGASHI Morihiro
金额：
$ 3.33万
依托单位：
Saitama Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

Mastermind (Mam) is a pivotal modulator of Notch signaling and has essential roles in the differentiation of B-cells from GC to MZ. We showed that 1) MamL1 and MamL3 were expressed in the GC and MZ of reactive lymph node. 2) Mam was expressed in 50% of cases with MC subtype of the Hodgkin lymphoma, whereas the expression was low in the cases with NS subtype. 3) Mam was expressed in the cases with follicular lymphoma and was low in the cases with marginal zone lymphoma. 4) The expression of Hes-1 was correlated with the expression of Notch1 or Jag2 in lymphoma cell lines, suggesting the Notch pathway is activated by cell-autonomously within lymphoma cell lines. 5) The expression of Hes-1 was correlated with LR11 expression. LR11 may be activated in parallel with Notch activation. Further investigation of the expression of Notch related molecules and the status of Notch activation is needed to clarify the biological and pathological differences in B-cell lymphomas originated from the GC.

Mastermind（MAM）是Notch信号的关键调节器，在B细胞从GC到MZ的分化中具有重要作用。我们表明1）MAML1和MAML3在反应性淋巴结的GC和MZ中表达。 2）在50％的霍奇金淋巴瘤MC亚型的病例中表达MAM，而在NS亚型的病例中，表达较低。 3）在卵泡淋巴瘤的病例中表达MAM，在边缘区域淋巴瘤的病例中较低。 4）HES-1的表达与淋巴瘤细胞系中Notch1或Jag2的表达相关，这表明Notch途径在淋巴瘤细胞系中被细胞自主激活。 5）HES-1的表达与LR11表达相关。 LR11可以与Notch激活并行激活。需要进一步研究Notch相关分子的表达以及需要Notch激活的状态，以阐明源自GC的B细胞淋巴瘤的生物学和病理差异。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow

G-CSF 诱导可溶形式 LR11 的释放，LR11 是骨髓中骨髓细胞动员的调节剂

DOI：
10.1007/s00277-014-2033-0
发表时间：
2014
期刊：
Ann Hematol
影响因子：
3.5
作者：
Shimizu N;Nakaseko C;Jiang M;Nishii K;Yokote K;Iseki T;Higashi M;Tamaru J;Schneider WJ;Bujo H
通讯作者：
Bujo H

Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL

DOI：
10.1158/1078-0432.ccr-11-2395
发表时间：
2012-04-15
期刊：
CLINICAL CANCER RESEARCH
影响因子：
11.5
作者：
Kanemitsu, Naoko;Isobe, Yasushi;Komatsu, Norio
通讯作者：
Komatsu, Norio

Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma

DOI：
10.3109/10428194.2014.880430
发表时间：
2014-01
期刊：
Leukemia & Lymphoma
影响因子：
2.6
作者：
T. Kawaguchi;C. Ohwada;M. Takeuchi;N. Shimizu;E. Sakaida;Y. Takeda;S. Sakai;S. Tsukamoto;Atsuko Yamazaki;Y. Sugita;M. Higashi;K. Fujikawa;K. Matsue;K. Yokote;J. Tamaru;H. Bujo;C. Nakaseko
通讯作者：
T. Kawaguchi;C. Ohwada;M. Takeuchi;N. Shimizu;E. Sakaida;Y. Takeda;S. Sakai;S. Tsukamoto;Atsuko Yamazaki;Y. Sugita;M. Higashi;K. Fujikawa;K. Matsue;K. Yokote;J. Tamaru;H. Bujo;C. Nakaseko

Somatic Mutations in PIK3CA and Activation of AKT in Intraductal Tubulopapillary Neoplasms of the Pancreas