The role of Mastermind in B-cell lymphoma

Mastermind 在 B 细胞淋巴瘤中的作用

• 批准号: 23590413
• 负责人: HIGASHI Morihiro
• 金额: $ 3.33万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590413/
• 关键词: 血液; B細胞性リンパ腫; Mastermind; Notch; 悪性リンパ腫; 腫瘍発生機構; LR11; Notchシグナル; 免疫組織化学; Matermind

Mastermind (Mam) is a pivotal modulator of Notch signaling and has essential roles in the differentiation of B-cells from GC to MZ. We showed that 1) MamL1 and MamL3 were expressed in the GC and MZ of reactive lymph node. 2) Mam was expressed in 50% of cases with MC subtype of the Hodgkin lymphoma, whereas the expression was low in the cases with NS subtype. 3) Mam was expressed in the cases with follicular lymphoma and was low in the cases with marginal zone lymphoma. 4) The expression of Hes-1 was correlated with the expression of Notch1 or Jag2 in lymphoma cell lines, suggesting the Notch pathway is activated by cell-autonomously within lymphoma cell lines. 5) The expression of Hes-1 was correlated with LR11 expression. LR11 may be activated in parallel with Notch activation. Further investigation of the expression of Notch related molecules and the status of Notch activation is needed to clarify the biological and pathological differences in B-cell lymphomas originated from the GC.

Mam是Notch信号传导的关键调节剂，在B细胞从GC分化为MZ中起重要作用。结果表明：1）MamL 1和MamL 3在反应性淋巴结的GC和MZ中均有表达; 2)MAm在霍奇金淋巴瘤MC亚型中的表达率为50%，而在NS亚型中的表达率较低。3)MAm在滤泡性淋巴瘤中呈阳性表达，在边缘区淋巴瘤中呈低表达。4)在淋巴瘤细胞系中Hes-1的表达与Notch 1或Jag 2的表达相关，表明Notch通路在淋巴瘤细胞系中被细胞自主激活。5)Hes-1的表达与LR 11的表达相关。LR 11可以与Notch激活并行激活。需要进一步研究Notch相关分子的表达和Notch激活状态，以阐明起源于GC的B细胞淋巴瘤的生物学和病理学差异。

项目成果

G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow

G-CSF 诱导可溶形式 LR11 的释放，LR11 是骨髓中骨髓细胞动员的调节剂

• DOI: 10.1007/s00277-014-2033-0
• 发表时间: 2014
• 期刊: Ann Hematol
• 影响因子: 3.5
• 作者: Shimizu N;Nakaseko C;Jiang M;Nishii K;Yokote K;Iseki T;Higashi M;Tamaru J;Schneider WJ;Bujo H
• 通讯作者: Bujo H

Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL

• DOI: 10.1158/1078-0432.ccr-11-2395
• 发表时间: 2012-04-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Kanemitsu, Naoko;Isobe, Yasushi;Komatsu, Norio
• 通讯作者: Komatsu, Norio

悪性リンパ腫におけるLR11発現と意義

LR11在恶性淋巴瘤中的表达及意义

• 发表时间: 2012
• 作者: 東守洋;得平道英;川口岳晴;竹内正博;大和田千佳子;中世古知明;武成英明;木崎昌弘;田丸淳一
• 通讯作者: 田丸淳一

Expression of LR11 in malignant lymphoma

LR11在恶性淋巴瘤中的表达

• 发表时间: 2011
• 作者: 東守洋;得平道英;川口岳晴;竹内正博;大和田千佳子;中世古知明;武成英明;木崎昌弘;田丸淳一
• 通讯作者: 田丸淳一

【分子病態からみた血液疾患診療の進歩】ホジキンリンパ腫の病態解析の新展開

【分子病理学视角下血液病治疗进展】霍奇金淋巴瘤病理分析新进展

• 发表时间: 2011
• 期刊: 血液内科
• 作者: Yamaguchi H;Kuboki Y;Hatori T;Yamamoto M;Shiratori K;Kawamura S;Kobayashi M;Shimizu M;Ban S;Koyama I;Higashi M;et. al;東守洋,田丸淳一
• 通讯作者: 東守洋,田丸淳一