The role of Mastermind in B-cell lymphoma

Mastermind （Mam）是Notch信号的关键调节剂，在b细胞从GC向MZ的分化过程中起着重要作用。我们发现1)MamL1和MamL3在反应性淋巴结的GC和MZ中表达。2) Mam在50%的MC亚型霍奇金淋巴瘤中表达，而在NS亚型中表达较低。3)滤泡性淋巴瘤表达Mam，边缘区淋巴瘤表达Mam较低。4)淋巴瘤细胞系中Hes-1的表达与Notch1或Jag2的表达相关，表明Notch通路在淋巴瘤细胞系中被细胞自主激活。5) he -1表达与LR11表达相关。LR11可能在Notch激活的同时被激活。为了阐明GC源性b细胞淋巴瘤的生物学和病理学差异，需要进一步研究Notch相关分子的表达和Notch激活状态。

Mastermind (Mam) is a pivotal modulator of Notch signaling and has essential roles in the differentiation of B-cells from GC to MZ. We showed that 1) MamL1 and MamL3 were expressed in the GC and MZ of reactive lymph node. 2) Mam was expressed in 50% of cases with MC subtype of the Hodgkin lymphoma, whereas the expression was low in the cases with NS subtype. 3) Mam was expressed in the cases with follicular lymphoma and was low in the cases with marginal zone lymphoma. 4) The expression of Hes-1 was correlated with the expression of Notch1 or Jag2 in lymphoma cell lines, suggesting the Notch pathway is activated by cell-autonomously within lymphoma cell lines. 5) The expression of Hes-1 was correlated with LR11 expression. LR11 may be activated in parallel with Notch activation. Further investigation of the expression of Notch related molecules and the status of Notch activation is needed to clarify the biological and pathological differences in B-cell lymphomas originated from the GC.