The role of Mastermind in B-cell lymphoma

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Mastermind (Mam) is a pivotal modulator of Notch signaling and has essential roles in the differentiation of B-cells from GC to MZ. We showed that 1) MamL1 and MamL3 were expressed in the GC and MZ of reactive lymph node. 2) Mam was expressed in 50% of cases with MC subtype of the Hodgkin lymphoma, whereas the expression was low in the cases with NS subtype. 3) Mam was expressed in the cases with follicular lymphoma and was low in the cases with marginal zone lymphoma. 4) The expression of Hes-1 was correlated with the expression of Notch1 or Jag2 in lymphoma cell lines, suggesting the Notch pathway is activated by cell-autonomously within lymphoma cell lines. 5) The expression of Hes-1 was correlated with LR11 expression. LR11 may be activated in parallel with Notch activation. Further investigation of the expression of Notch related molecules and the status of Notch activation is needed to clarify the biological and pathological differences in B-cell lymphomas originated from the GC.