Detection of effective compounds for inhibiting inflammation-related carcinogenesis

检测抑制炎症相关癌变的有效化合物

• 批准号: 23590461
• 负责人: OKADA Futoshi
• 金额: $ 3.33万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590461/
• 关键词: 炎症発癌; 化合物; 炎症細胞; 阻害化合物; 発癌予防; 浸出阻止

The purpose of this study is to identify chemopreventive compounds that inhibit inflammation-related carcinogenesis. Inflammation-related carcinogenesis is initiated by massive infiltration of inflammatory cells into an inflamed lesion. I found several compounds that inhibit the infiltration by using in vitro screening model. Among them, I found that a compound had the strongest inhibitory effects on the inflammatory cell infiltration, and that it inhibited foreign body-induced inflammation-related carcinogenesis in a mouse model. DNA array revealed that expressions of inflammation-related molecules such as NF-kB-related molecules were inhibited. Then, I determined minimum structure of the compound that will be responsible for the inhibition of inflammation.

本研究的目的是确定化学预防化合物，抑制炎症相关的致癌作用。炎症相关的致癌作用是由炎性细胞大量浸润到炎症病变中引发的。通过体外筛选模型，发现了几种抑制浸润的化合物。其中，我发现一种化合物对炎性细胞浸润的抑制作用最强，并且在小鼠模型中抑制了异物诱导的炎症相关的致癌作用。DNA微阵列显示，炎症相关分子如NF-κ B相关分子的表达受到抑制。然后，我确定了负责抑制炎症的化合物的最小结构。

项目成果

How aging and cellular senescence influence metastasis. In : Cancermetastasis : biologic basis and therapeutic

衰老和细胞衰老如何影响转移。

• 发表时间: 2011
• 作者: Okada F;Kobayashi H
• 通讯作者: Kobayashi H

炎症浸出の阻害化合物探索による炎症発癌の抑制

通过寻找抑制炎症渗出的化合物来抑制炎症癌变

• 发表时间: 2013
• 作者: 横溝千尋;山口寛二;西村健;光吉博則;安居幸一郎;南祐仁;岩井眞樹;伊藤義人;吉川敏一;Yamato I;Shinya MIZUNO and Yoko MIZUNO-HORIKAWA;岡田太
• 通讯作者: 岡田太

Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical

癌症和炎症机制：化学、生物和临床

• 发表时间: 2013
• 作者: Katayama K;Asano K;Shimamura N;Ogasawara Y;Naraoka M;Ohkuma H;Kurose A;Okada F
• 通讯作者: Okada F

低酸素再酸素化環境と発癌・悪性化の進展

缺氧复氧环境与癌变和恶性肿瘤的进展

• 发表时间: 2011
• 作者: 島田啓司;藤井智美;穴井智;藤本清秀;小西登;岡田太
• 通讯作者: 岡田太

Inflammation as a niche for tumor progression. In : Cancer and Inflammation Mechanisms : Chemical, Biological, and Clinical Aspects

炎症是肿瘤进展的利基。

• 发表时间: 2014
• 作者: Okada F;(Eds. Y Hiraku;S Kawanishi and H Ohshima)
• 通讯作者: S Kawanishi and H Ohshima)