Detection of effective compounds for inhibiting inflammation-related carcinogenesis

本研究的目的是确定化学预防化合物，抑制炎症相关的致癌作用。炎症相关的致癌作用是由炎性细胞大量浸润到炎症病变中引发的。通过体外筛选模型，发现了几种抑制浸润的化合物。其中，我发现一种化合物对炎性细胞浸润的抑制作用最强，并且在小鼠模型中抑制了异物诱导的炎症相关的致癌作用。DNA微阵列显示，炎症相关分子如NF-κ B相关分子的表达受到抑制。然后，我确定了负责抑制炎症的化合物的最小结构。

The purpose of this study is to identify chemopreventive compounds that inhibit inflammation-related carcinogenesis. Inflammation-related carcinogenesis is initiated by massive infiltration of inflammatory cells into an inflamed lesion. I found several compounds that inhibit the infiltration by using in vitro screening model. Among them, I found that a compound had the strongest inhibitory effects on the inflammatory cell infiltration, and that it inhibited foreign body-induced inflammation-related carcinogenesis in a mouse model. DNA array revealed that expressions of inflammation-related molecules such as NF-kB-related molecules were inhibited. Then, I determined minimum structure of the compound that will be responsible for the inhibition of inflammation.