Th2 independent NB expulsion by natural helper cells
Th2 independent NB expulsion by natural helper cells
批准号:
23590488
负责人:
HONMA Kiri
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Interferon regulatory factor 4 (IRF4) is the development of Th2. In IRF4-deficient mice (IRF4 KO), Th2 development does not occur. Nippostrongyrus brasiliensis (NB) is one of parasite and is eliminated by antigen-specific Th2, which is generated during infection. However, Th2 independent NB elimination was found in IRF4 KO. This study indicated that group2 innate lymphocytes (ILC2) played the crucial role in Th2 independent NB expulsion and IRF4 directly regulated the Th2 cytokine production, such as IL5 or IL13 although IRF4 was dispensable of ILC2 development.
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マラリア原虫感染における特異的記憶CD8^+T細胞の分化
疟疾寄生虫感染中特异性记忆CD8^+ T细胞的分化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[都田真奈, 木村大輔, 本間季里, 木村一美, 油田正夫, 由井克之]
通讯作者:
由井克之
IRF-4欠損MRL/lprマウスはTh1過剰応答を起こし複数の組織に肉芽腫性病変を発症する
IRF-4 缺陷的 MRL/lpr 小鼠表现出 Th1 高反应并在多个组织中出现肉芽肿性病变。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Machida Takeshi, Honma Kiri, Matsuyama Toshifumi, Yui Katsuyuki, Ruiz Phil, Fujita Teizo, Gilkeson Gary, Sekine Hideharu]
通讯作者:
Sekine Hideharu
マラリア原虫特異的CD4T細胞はEBI3陽性サイトカイン介して他のCD4T細胞のIL-2産生を抑制する
疟原虫特异性 CD4T 细胞通过 EBI3 阳性细胞因子抑制其他 CD4T 细胞产生 IL-2
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[木村大輔, 都田真奈, 本間季里, 木村一美, 原博満, 吉田裕樹, 由井克之]
通讯作者:
由井克之
IRF4 controls cytokine signals and plays critical roles for proliferation and differentiation of CD8+ T cells.
IRF4 控制细胞因子信号,对 CD8 T 细胞的增殖和分化发挥关键作用。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[MIYAKODA Mana, HONMA Kiri, KIMURA Daisuke, KIMURA Kazumi, MATSUYAMA Toshifumi, YUI Katsuyuki]
通讯作者:
YUI Katsuyuki
CD19(+) B cells confer protection against experimental cerebral malaria in semi-immune rodent model.
DOI:
10.1371/journal.pone.0064836
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Bao LQ, Huy NT, Kikuchi M, Yanagi T, Senba M, Shuaibu MN, Honma K, Yui K, Hirayama K]
通讯作者:
Hirayama K
共 36 条
Regulation of IL12 production in the induction of protective immune response against Leishmania infection
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批准号:20590424
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2008
-
负责人:HONMA Kiri
-
依托单位:
New recognition of Leishmania major by infected macrophages
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批准号:18590401
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
-
负责人:HONMA Kiri
-
依托单位:
Molecular mechanisms To protect malaria infection by vaccine using antigen / hsp70 fusion protein
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批准号:13670248
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:HONMA Kiri
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依托单位:
海外基金