Regulation of IL12 production in the induction of protective immune response against Leishmania infection

与抗性小鼠相比，利什曼原虫感染后IRF4 KO中足垫肿胀的减少显示是由于使用条件性KO的实验中树突状细胞而不是巨噬细胞中IRF4的缺陷。与脾脏DC不同，在IRF 4 KO的淋巴结中观察到CD4+ DC亚群。提示LN中DC的分化与脾脏中DC的分化不同。在感染后48小时内，IRF 4 KO中的CD 103 + DC（一种皮肤DC）的募集比WT慢。

Reduction of footpad swelling in IRF4 KO after Leishmania infection compared to resistant mice revealed to be due to defect of IRF4 in dendritic cells not macrophages by the experiments using conditional KO. Unlike splenic DC, CD4+ DC subset was observed in lymph node in IRF4 KO. It suggested that DC differentiation in LN was different from that in spleen. Recruitment of CD103+ DC, which was a kind of skin DC, in IRF4 KO was slower than WT within 48 hrs after infection.