Regulation of IL12 production in the induction of protective immune response against Leishmania infection

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Reduction of footpad swelling in IRF4 KO after Leishmania infection compared to resistant mice revealed to be due to defect of IRF4 in dendritic cells not macrophages by the experiments using conditional KO. Unlike splenic DC, CD4+ DC subset was observed in lymph node in IRF4 KO. It suggested that DC differentiation in LN was different from that in spleen. Recruitment of CD103+ DC, which was a kind of skin DC, in IRF4 KO was slower than WT within 48 hrs after infection.