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Severe pathology in pregnant mice during malaria

疟疾期间怀孕小鼠的严重病理学

基本信息

批准号：
23590493
负责人：
KOBAYASHI Fumie
金额：
$ 3.41万
依托单位：
Kyorin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

In this study, we established a mouse model of pathological features of pregnant women living in malaria-endemic regions and investigated the pathogenesis of malaria during pregnancy using the mouse model. Pregnant mice immunized by infection of nonlethal Plasmodium berghei (Pb) XAT were more susceptible to lethal Pb NK65 challenged infection than non-pregnant mice and showed high levels of parasitemia and poor pregnancy outcome associated with placental pathology in late phase of pregnancy. Notably, the pregnant immunized mice infected with Pb NK65 developed liver injury in late phase of pregnancy. Higher levels of IFN-gamma and NO were observed in plasma from pregnant immunized mice infected with Pb NK65 compared with those in non-pregnant immunized mice infected with Pb NK65. These findings suggest that development of liver injury and placental pathology in pregnant immunized mice infected with Pb NK65 are associated with enhanced production of pro-inflammatory cytokines.

本研究建立了疟疾流行区孕妇病理特征的小鼠模型，并利用该模型研究了妊娠期疟疾的发病机制。非致死性伯氏疟原虫（Pb）XAT感染免疫的孕鼠比非孕鼠更易受到致死性Pb NK 65攻击感染，并表现出高水平的寄生虫血症和妊娠晚期胎盘病理学相关的不良妊娠结局。值得注意的是，妊娠免疫小鼠感染Pb NK 65后，在妊娠后期出现肝损伤。妊娠期免疫小鼠感染Pb NK 65后，血浆中IFN-γ和NO水平明显高于非妊娠期免疫小鼠。这些发现表明，在妊娠免疫小鼠感染铅NK 65的肝损伤和胎盘病理的发展与促炎细胞因子的产生增强。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

妊娠マラリアの病態に関わる新たな宿主因子の探索.Development of liver dysfunction in immunized pregnant mice challenged with lethal malaria parasites

寻找与妊娠疟疾病理学相关的新宿主因素。受到致命疟原虫攻击的免疫妊娠小鼠出现肝功能障碍

DOI：
发表时间：
2013
期刊：
影响因子：
0
作者：
Meng Feng;Junlong Cai;Xiangyang Min;Yonggeng Fu;Qing Xu;Hiroshi Tachibana and Xunjia Cheng;都田真奈;峯尾松一郎,新倉保,井上信一,井上愛美,黒田雅彦,小林富美惠
通讯作者：
峯尾松一郎,新倉保,井上信一,井上愛美,黒田雅彦,小林富美惠

妊娠マラリアの病態に関わる新たな宿主因子の探索

寻找与妊娠期疟疾病理学相关的新宿主因素