Effect of a potential Chlamydial effecter protein, CpB0850 on cell cycle progression of host cells

潜在的衣原体效应蛋白 CpB0850 对宿主细胞细胞周期进程的影响

• 批准号: 23590505
• 负责人: HIRAI Itaru
• 金额: $ 3.33万
• 依托单位: University of the Ryukyus (2013)Osaka University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590505/
• 关键词: 遺伝子; 細菌; 微生物; 肺炎クラミジア; 細胞周期

In this study, we examined effect of Chlamydophila pneumoniae infection on host cells. Cell growth of host cells were suppressed by C. pneumoniae infection through modification of certain signal transduction pathway. In addition, it was suggested that a potential Chlamydial effector protein, CpB0850 might effect on cell cycle progression through interaction with host cellular chromosomal protein.

在这项研究中，我们研究了肺炎衣原体感染对宿主细胞的影响。C. pneumoniae感染通过修饰某些信号转导通路。此外，CpB0850可能是一种潜在的衣原体效应蛋白，它可能通过与宿主细胞染色体蛋白相互作用而影响细胞周期进程。

项目成果

Dissemination of CTX-M type ESBL-producing bacteria in Southeast Asian countries

CTX-M型产ESBL细菌在东南亚国家的传播

• 发表时间: 2014
• 作者: Nemoto H;Kataoka K;Ishikawa H;Ikata K;Arimochi H;Iwasaki T;Ohnishi Y;Kuwahara T;Yasutomo K;友安 俊文;Itaru Hirai
• 通讯作者: Itaru Hirai

Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K.

• DOI: 10.1016/j.imbio.2012.06.008
• 发表时间: 2013-04
• 期刊: Immunobiology
• 影响因子: 2.8
• 作者: I. Hirai;M. Ebara;Shoko Nakanishi;Chihiro Yamamoto;Tadahiro Sasaki;K. Ikuta;Yoshimasa Yamamoto

Detection of chromosomal blaCTX-M-15 in Escherichia coli O25b-B2-ST131 isolates from the Kinki region of Japan

• DOI: 10.1016/j.ijantimicag.2013.08.005
• 发表时间: 2013-12-01
• 期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
• 影响因子: 10.8
• 作者: Hirai, Itaru;Fukui, Naoki;Yamamoto, Yoshimasa
• 通讯作者: Yamamoto, Yoshimasa

Fecal carriage of CTX-M β-lactamase-producing Enterobacteriaceae in nursing homes in the Kinki region of Japan.

• DOI: 10.2147/idr.s43868
• 发表时间: 2013
• 期刊: Infection and drug resistance
• 影响因子: 3.9
• 作者: Luvsansharav UO;Hirai I;Niki M;Nakata A;Yoshinaga A;Yamamoto A;Yamamoto M;Toyoshima H;Kawakami F;Matsuura N;Yamamoto Y
• 通讯作者: Yamamoto Y

Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthy adult people in Japan

• DOI: 10.1007/s10156-011-0225-2
• 发表时间: 2011-10-01
• 期刊: JOURNAL OF INFECTION AND CHEMOTHERAPY
• 影响因子: 2.2
• 作者: Luvsansharav, Ulzii-Orshikh;Hirai, Itaru;Yamamoto, Yoshimasa
• 通讯作者: Yamamoto, Yoshimasa