Control itch in atopic dermatitis

控制特应性皮炎的瘙痒

• 批准号: 23590708
• 负责人: AMANO HIROO
• 金额: $ 3.33万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590708/
• 关键词: atopic dermatitis; itching; stress; opioid; アトピー性皮膚炎; 痒み; ストレス; オピオイド

Atopic dermatitis is a common pruritic inflammatory skin disease. It has been well recognized that environmental factors such as mites and dusts and psychological stress exacerbate atopic dermatitis. We have demonstrated that psychological stress by itself can induce scratching behaviour and trigger atopic dermatitis-like skin changes in atopic dermatitis model mice, NC/Nga. Psychological stress decreased peripheral blood and spleen NK cells, and the mRNA expression of kappa-opioid receptors in brain. On the other hand, psychological stress increased the mRNA expression of u-opioid receptors in brain. Our data suggest that the control of opioid receptor expression and NK cell profile may suppress stress-induced scratching behavior, and lead to a new treatment of atopic dermatitis.

特应性皮炎是一种常见的皮炎性炎症性皮肤病。 众所周知，环境因素如螨和灰尘以及心理压力会加重特应性皮炎。我们已经证明，心理压力本身可以诱导抓挠行为，并触发特应性皮炎模型小鼠，NC/Nga的特应性皮炎样皮肤变化。心理应激降低外周血和脾脏NK细胞及脑内κ-阿片受体mRNA表达。另一方面，心理应激可增加脑内μ-阿片受体mRNA的表达。我们的数据表明，阿片受体表达和NK细胞的控制可能会抑制应激诱导的抓挠行为，并导致一个新的治疗特应性皮炎。

项目成果

Brain opioid receptor responses to psychological stress in atopic dermatitis model mice, NC/Nga

特应性皮炎模型小鼠大脑阿片受体对心理应激的反应，NC/Nga

• 发表时间: 2012
• 作者: Amano H;Kishi C;Yasuda M;Akiyama H;Ishikawa O
• 通讯作者: Ishikawa O

Brain opioid receptor responses to psychological stress in atopic dermatitis model mice. 22^<nd> World Congress of Dermatology

特应性皮炎模型小鼠大脑阿片受体对心理压力的反应。

• 发表时间: 2011
• 作者: Amano H;Kishi C;Yasuda M;Negishi I;Akiyama H;Ishikawa O
• 通讯作者: Ishikawa O

Symmetric lipomatosis of the inner side of the knee: A case report and a review of the literature

膝内侧对称性脂肪增多症一例报告并文献复习

• DOI: 10.2340/00015555-1585
• 发表时间: 2013
• 期刊: Acta Derm Venereol
• 作者: Amano H;Kishi C;Shimizu A;Ishikawa O.
• 通讯作者: Ishikawa O.

Microsporum canis infection mimics pemphigus erythematosus.

• DOI: 10.4103/0019-5154.110866
• 发表时间: 2013-05
• 期刊: Indian journal of dermatology
• 影响因子: 1.7
• 作者: Amano H;Kishi C;Yokoyama Y;Shimizu A;Anzawa K;Mochizuki T;Ishikawa O
• 通讯作者: Ishikawa O

Brain opioid receptor responses to psychological stress in atopic dermatitis model mice.

特应性皮炎模型小鼠大脑阿片受体对心理压力的反应。

• 发表时间: 2011
• 作者: Amano H;Kishi C;Yasuda M;Negishi I;Akiyama H;Ishikawa O
• 通讯作者: Ishikawa O