The effects of maternal exposure of persistent organochlorine pesticides on allergic and infection's symptoms in infancy

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Previous studies suggest that persistent organochlorine (POC) pesticides may contribute to endocrine disruption. The purpose of this study was to investigate the association between POCs levels in maternal blood and the risk of allergies in infancy. Between 2002 and 2005, 514 pregnant women were recruited in Sapporo Toho Hospital, and 29 POC pesticides in 320 whole blood samples were measured. No associations between POC pesticides levels and allergic symptoms at 18 month of age were observed in adjusted logistic regression analysis. At background levels, prenatal exposure to POC pesticides may alter immune function during childhood. Therefore, more long-term observations are needed to assess whether developmental exposure may result in allergic diseases in later childhood.