A longitudinal study on the relation between overall sleep status and subsequent changes in serum high-sensitivity C-reactive protein

整体睡眠状态与血清高敏C反应蛋白后续变化关系的纵向研究

• 批准号: 23590817
• 负责人: NAKAMURA Koshi
• 金额: $ 3.33万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590817/
• 关键词: 睡眠; 炎症; 縦断研究; 高感度C-反応性蛋白; 追跡調査

We investigated the relation between overall sleep status based on the global score of a partially-modified version of Pittsburgh Sleep Quality Index (PSQI) and subsequent changes in serum high-sensitivity C-reactive protein (hsCRP) in 991 middle-aged Japanese factory workers without increased and potentially pathogenic levels of inflammation (hsCRP at year 3 >= 1.0 mg/L). The subsequent changes in hsCRP after 3 years were grater in subjects with unfavorable sleep habits, defined as a PSQI global score > 5.5 points, compared with those with a normal pattern. The geometric means of hsCRP at year 3 were 0.275 mg/L and 0.242 mg/L, respectively, after adjusting for baseline hsCRP and other potential confounders (p=0.04). The multivariate-adjusted odds ratio for developing that inflammation due to unfavorable sleep was 2.08 (1.29-3.35). Unfavorable sleep is associated with activation of low-grade systemic inflammation.

我们调查了基于匹兹堡睡眠质量指数（PSQI）的部分修改版本的总体评分的总体睡眠状态与血清高敏C反应蛋白（hsCRP）随后变化之间的关系，这些中年日本工厂工人没有增加和潜在致病性炎症水平（hsCRP在第3年>= 1.0 mg/L）。与正常模式的受试者相比，睡眠习惯不良（定义为PSQI总分> 5.5分）的受试者3年后hsCRP的变化更大。校正基线hsCRP和其他潜在混杂因素后，第3年hsCRP的几何平均值分别为0.275 mg/L和0.242 mg/L（p=0.04）。由于睡眠不良而发生炎症的多变量调整比值比为2.08（1.29-3.35）。不良睡眠与低度全身性炎症的激活有关。

项目成果

Overall sleep status and high sensitivity C‐reactive protein: a prospective study in Japanese factory workers

整体睡眠状态与高敏 C 反应蛋白：一项针对日本工厂工人的前瞻性研究

• 发表时间: 2014
• 期刊: Journal of Sleep Research
• 影响因子: 4.4
• 作者: K. Nakamura;M. Sakurai;K. Miura;Y. Morikawa;S. Nagasawa;M. Ishizaki;T. Kido;Y. Naruse;M. Nakashima;K. Nogawa;Y. Suwazono;H. Nakagawa
• 通讯作者: H. Nakagawa