A longitudinal study on the relation between overall sleep status and subsequent changes in serum high-sensitivity C-reactive protein

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We investigated the relation between overall sleep status based on the global score of a partially-modified version of Pittsburgh Sleep Quality Index (PSQI) and subsequent changes in serum high-sensitivity C-reactive protein (hsCRP) in 991 middle-aged Japanese factory workers without increased and potentially pathogenic levels of inflammation (hsCRP at year 3 >= 1.0 mg/L). The subsequent changes in hsCRP after 3 years were grater in subjects with unfavorable sleep habits, defined as a PSQI global score > 5.5 points, compared with those with a normal pattern. The geometric means of hsCRP at year 3 were 0.275 mg/L and 0.242 mg/L, respectively, after adjusting for baseline hsCRP and other potential confounders (p=0.04). The multivariate-adjusted odds ratio for developing that inflammation due to unfavorable sleep was 2.08 (1.29-3.35). Unfavorable sleep is associated with activation of low-grade systemic inflammation.