Overall sleep status and high sensitivity C‐reactive protein: a prospective study in Japanese factory workers
Overall sleep status and high sensitivity C‐reactive protein: a prospective study in Japanese factory workers
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整体睡眠状态与高敏 C 反应蛋白：一项针对日本工厂工人的前瞻性研究
DOI：
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发表时间：
2014
影响因子：
4.4
通讯作者：
H. Nakagawa
中科院分区：
文献类型：
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作者：
K. Nakamura;M. Sakurai;K. Miura;Y. Morikawa;S. Nagasawa;M. Ishizaki;T. Kido;Y. Naruse;M. Nakashima;K. Nogawa;Y. Suwazono;H. Nakagawa
我们研究了基于改良匹兹堡睡眠质量指数（PSQI）总体评分的总体睡眠状态与日本工厂工人人群（主要是女性）血清高敏C反应蛋白（hsCRP）随后变化之间的关系。共有991名患有炎症的日本人被归类为低心血管风险（基线hsCRP < 1.0 mg L-1），根据是否存在不良睡眠进行分组，定义为改良的PSQI总体评分> 5.5分。比较两组患者治疗3年后hsCRP的变化。采用协方差分析，结合对数转换的基线hsCRP、年龄、性别、生活方式以及身体和生化特征，比较每个睡眠状态组第3年hsCRP的几何平均值。使用包含相同变量的logistic回归模型计算炎症发展的优势比，并比较存在或不存在不良睡眠习惯的情况，具有中至高心血管风险（第3年hsCRP ≥ 1.0 mg L−1）。与睡眠模式正常的受试者相比，睡眠习惯不良的受试者第3年hsCRP的多变量校正几何平均值显著较高（0.275 vs 0.242 mg L−1）。由于睡眠不良而导致炎症水平升高和潜在致病水平的多变量调整比值比为2.08（95%置信区间= 1.29-3.35）。在改良的PSQI总体评分中，炎症增加的发展存在显著的线性趋势（P = 0.04）。不良睡眠与低度全身性炎症的激活有关。
We investigated the relation between overall sleep status based on the modified Pittsburgh Sleep Quality Index (PSQI) global score and subsequent changes in serum high‐sensitivity C‐reactive protein (hsCRP) in a population of Japanese factory workers, who were predominantly female. A total of 991 Japanese with inflammation classified as low cardiovascular risk (baseline hsCRP < 1.0 mg L−1) were grouped according to the presence or absence of unfavourable sleep, defined as a modified PSQI global score > 5.5 points. The subsequent changes in hsCRP after 3 years were then compared in the two groups. Analysis of covariance incorporating log‐transformed baseline hsCRP, age, sex, lifestyle and physical and biochemical profiles was used to compare the geometric means of hsCRP at year 3 in each sleep status group. A logistic regression model incorporating the same variables was used to calculate the odds ratios for development of inflammation with a medium‐to‐high cardiovascular risk (hsCRP at year 3 ≥ 1.0 mg L−1) comparing the presence or absence of unfavourable sleep habits. The multivariate‐adjusted geometric mean of hsCRP at year 3 was significantly higher in subjects with unfavourable sleep habits compared with those with a normal pattern (0.275 versus 0.242 mg L−1). The multivariate‐adjusted odds ratio for developing increased and potentially pathogenic levels of inflammation due to unfavourable sleep was 2.08 (95% confidence interval = 1.29–3.35). There was a significant linear trend for the development of increased inflammation across the modified PSQI global scores (P = 0.04). Unfavourable sleep is associated with activation of low‐grade systemic inflammation.
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DOI：
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发表时间：
2012
期刊：
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影响因子：
--
作者：
U. C. Ojha
通讯作者：
U. C. Ojha
影响因子：
5
作者：
Ferrie, Jane E.;Kivimaeki, Mika;Shipley, Martin J.
通讯作者：
Shipley, Martin J.
影响因子：
5.6
作者：
Patel, Sanjay R.;Zhu, Xiaobei;Redline, Susan
通讯作者：
Redline, Susan
影响因子：
5.6
作者：
Dowd, Jennifer Beam;Goldman, Noreen;Weinstein, Maxine
通讯作者：
Weinstein, Maxine
自我报告的睡眠质量与全身炎症和凝血生物标志物的前瞻性关联的性别差异：心与灵魂研究的结果。
影响因子：
4.8
作者：
Prather,AricA;Epel,ElissaS;Cohen,BethE;Neylan,ThomasC;Whooley,MaryA
通讯作者：
Whooley,MaryA