Establishment of objective index markers for the mental health problem in workers

职工心理健康问题客观指标体系的建立

• 批准号: 23590825
• 负责人: KURATSUNE HIROHIKO
• 金额: $ 3.41万
• 依托单位: Kansai University of Welfare Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590825/
• 关键词: 健康診断; メンタルヘルス障害; 自律神経機能; 睡眠・覚醒リズム; 酸化ストレス; 抗酸化力; 疲労; 抑うつ; 睡眠異常

To clarify the objective features of the fatigue state, we investigated subjective symptoms, autonomic nerve function, physical activities, and sleep parameters in 207 college students and 430 staff members of a school that had been affected by the Great East Japan Earthquake in A-city, and 304 staff members of a school in west Japan. College students study suggests that autonomic nerve function is related to the fatigue symptoms, physical activities, and sleep parameters. Furthermore, the study for the staff members of a school indicates that both members in A-city and west Japan have not only severe fatigue symptoms, but also sympathetic hyperactivity, low awake activity and increase counts of catnaps during waking hours.These data suggests that autonomic nerve function is clearly related to the fatigue symptoms, physical activities, and sleep parameters, and that it is a possible to make a diagnostic algorithm for fatigue state by using these objective index markers.

为了明确疲劳状态的客观特征，我们调查了受东日本大地震影响的A市一所学校的207名大学生和430名工作人员以及日本西部一所学校的304名工作人员的主观症状，自主神经功能，体力活动和睡眠参数。大学生自主神经功能与疲劳症状、体力活动、睡眠参数有关。此外，对一所学校的工作人员进行的研究表明，A市和西日本的工作人员不仅有严重的疲劳症状，而且交感神经功能亢进，清醒时活动减少，清醒时小睡次数增加。这些数据表明，自主神经功能与疲劳症状，体力活动和睡眠参数明显相关。并且可以通过使用这些客观指标标记来制定疲劳状态的诊断算法。

项目成果

慢性疲労症候群と睡眠障害

慢性疲劳综合症和睡眠障碍

• 作者: 中富康仁;倉恒弘彦;吉田政樹;稲葉雅章;渡辺恭良。
• 通讯作者: 渡辺恭良。

Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.

• DOI: 10.1371/journal.pone.0051515
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yamamoto S;Ouchi Y;Nakatsuka D;Tahara T;Mizuno K;Tajima S;Onoe H;Yoshikawa E;Tsukada H;Iwase M;Yamaguti K;Kuratsune H;Watanabe Y
• 通讯作者: Watanabe Y

Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis.

• DOI: 10.1016/j.cca.2012.05.004
• 发表时间: 2012-10
• 期刊: Clinica chimica acta; international journal of clinical chemistry
• 作者: A. Sakudo;H. Kuratsune;Y. Kato;K. Ikuta

Association of monoamine-synthesizing genes with the temperament of chronic fatigue syndrome patients

单胺合成基因与慢性疲劳综合征患者气质的关系

• 发表时间: 2013
• 期刊: Life Sci
• 影响因子: 6.1
• 作者: Fukuda S.;Horiguchi M.;Yamaguti K.;Nakatomi Y.;Kuratsune H.;Ichinose H.,Watanabe Y.
• 通讯作者: Ichinose H.,Watanabe Y.

Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis : a ^11C-(R)-PK11195 positron emission tomography study

慢性疲劳综合征/肌痛性脑脊髓炎患者的神经炎症：^11C-(R)-PK11195 正电子发射断层扫描研究

• 发表时间: 2014
• 期刊: The Journal of Nuclear Medicine
• 作者: Yasuhito Nakatomi;Kei Mizuno;Akira Ishii;Yasuhiro Wada;Masaaki Tanaka;Shusaku Tazawa;Kayo Onoe;Sanae Fukuda;Joji Kawabe;Kazuhiro Takahashi;Yosky Kataoka;Susumu Shiomi;Kouzi Yamaguti;Masaaki Inaba;Hirohiko Kuratsune;Yasuyoshi Watanabe
• 通讯作者: Yasuyoshi Watanabe