Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.
Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor.
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DOI：
10.1371/journal.pone.0051515
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Watanabe Y
中科院分区：
文献类型：
--
作者：
Yamamoto S;Ouchi Y;Nakatsuka D;Tahara T;Mizuno K;Tajima S;Onoe H;Yoshikawa E;Tsukada H;Iwase M;Yamaguti K;Kuratsune H;Watanabe Y
脑反应性抗体与神经或精神症状之间的联系已经被提出。慢性疲劳综合征(CFS)或精神疾病患者血清抗M胆碱能受体(MAChR)自身抗体升高。我们用正电子发射断层扫描检测了自身抗体[CFs(+)]阳性[CFs(+)]和[CFs(−)]阴性的慢性阻塞性肺病患者的脑部mAChR结合和乙酰胆碱酯酶活性，以检验血清中抗mAChR自身抗体是否影响中枢胆碱能系统。对5例CFs(+)、6例CFs(−)患者和11例正常受试者进行了一系列的正电子发射计算机体层摄影检查，其中N-[11C]-3-哌啶基苯甲酸酯[11C](+)-3-mpb测定mAChR结合，N-[11C]甲基-4-哌乙酸甲酯[11C]mp4a测定乙酰胆碱酯酶活性。所有受试者的认知功能均采用神经心理学测验进行评定。尽管慢性疲劳综合征(−)患者脑内[11C](+)3-mpb结合率与正常对照组无明显差异，但cFS(+)患者脑内[11C](+)3-mpb结合率显著低于慢性阻塞性肺病(−)患者和正常对照组。相比之下，[11C]mp4a指数在这三组之间没有显著差异。不同组之间的神经心理测量结果相似。目前的结果表明，抗mAChR自身抗体可以影响脑mAChR，而不会改变CFS患者的乙酰胆碱酯酶活性和认知功能。
Numerous associations between brain-reactive antibodies and neurological or psychiatric symptoms have been proposed. Serum autoantibody against the muscarinic cholinergic receptor (mAChR) was increased in some patients with chronic fatigue syndrome (CFS) or psychiatric disease. We examined whether serum autoantibody against mAChR affected the central cholinergic system by measuring brain mAChR binding and acetylcholinesterase activity using positron emission tomography (PET) in CFS patients with positive [CFS(+)] and negative [CFS(−)] autoantibodies. Five CFS(+) and six CFS(−) patients, as well as 11 normal control subjects underwent a series of PET measurements with N-[11C]methyl-3-piperidyl benzilate [11C](+)3-MPB for the mAChR binding and N-[11C]methyl-4-piperidyl acetate [11C]MP4A for acetylcholinesterase activity. Cognitive function of all subjects was assessed by neuropsychological tests. Although the brain [11C](+)3-MPB binding in CFS(−) patients did not differ from normal controls, CFS(+) patients showed significantly lower [11C](+)3-MPB binding than CFS(−) patients and normal controls. In contrast, the [11C]MP4A index showed no significant differences among these three groups. Neuropsychological measures were similar among groups. The present results demonstrate that serum autoantibody against the mAChR can affect the brain mAChR without altering acetylcholinesterase activity and cognitive functions in CFS patients.
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影响因子：
10.5
作者：
AXELSSON, R;MARTENSSON, E;ALLING, C
通讯作者：
ALLING, C
影响因子：
11.2
作者：
AHLSKOG, JE;RICHELSON, E;CARMICHAEL, SW
通讯作者：
CARMICHAEL, SW
影响因子：
158.5
作者：
ENNA, SJ;BIRD, ED;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
4.7
作者：
Ganzinelli, S;Borda, T;Sterin-Borda, L
通讯作者：
Sterin-Borda, L
DOI：
10.1111/j.0142-5463.2004.00200.x
发表时间：
2004-02-01
影响因子：
2.3
作者：
Horikoshi, T.;Matsue, K.;Kajimoto, O.
通讯作者：
Kajimoto, O.