Development of new risk score of CHD and assement of new biomarkers based on Suita Cohort

基于Suita Cohort 开发新的冠心病风险评分并评估新的生物标志物

• 批准号: 23590835
• 负责人: NISHIMURA Kunihiro
• 金额: $ 3.49万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590835/
• 关键词: リスクスコア; バイオマーカー; コホート研究; 予測スコア; 循環器疫学; リスク評価; 大規模研究

Framingham risk score (FRS) is known as one of standard prediction tools for coronary heart disease (CHD) incidence. No previous study investigated its efficacy for Japanese population cohort. The purpose of this study was to make newly developed coronary prediction algorithms for a Japanese population in the manner of FRS compared with original FRS.Our coronary prediction algorithms for Japanese were based on a large population-based cohort study (Suita study). Study subjects comprised initially 5,886 healthy Japanese.The C-statistics showed the new model is better for accuracy than the original and recalibrated Framingham Scores. The net reclassification improvement (NRI) by the Suita score with inclusion of CKD was 41.2% (P<0.001) compared with the original FRS. Recalibration of FRS slightly improved the efficiency of the prediction, but still worse than the Suita score with CKD model. The Suita score with CKD predicted the risk of CHD more properly.

弗雷明汉风险评分（FRS）被称为冠心病（CHD）发病率的标准预测工具之一。之前没有研究调查其对日本人群的功效。本研究的目的是以 FRS 的方式与原始 FRS 进行比较，为日本人群制定新开发的冠状动脉预测算法。我们针对日本人的冠状动脉预测算法基于一项大型人群队列研究（吹田研究）。研究对象最初包括 5,886 名健康日本人。C 统计数据显示，新模型的准确性优于原始和重新校准的弗雷明汉评分。与原始 FRS 相比，包含 CKD 的 Suita 评分的净重分类改善 (NRI) 为 41.2% (P<0.001)。 FRS 的重新校准稍微提高了预测效率，但仍然比 CKD 模型的 Suita 评分差。 CKD 的 Suita 评分可以更准确地预测 CHD 的风险。

项目成果

DISTANT EFFECT OF AKI ON CELLULAR AS WELL AS SOLUBLE MEDIATORS IN BRONCHO-ALVEOLAR LAVAGE FLUID IN PATIENTS WITH ACUTE LUNG INJURY / ACUTE RESPIRATORY DISTRESS SYNDROME

AKI 对急性肺损伤/急性呼吸窘迫综合征患者支气管肺泡灌洗液中细胞和可溶性介质的远期影响

• 发表时间: 2012
• 作者: Hiroki Hayashi;Kunihiro Nishimura;Shouichi Maruyama;Yukio Yuzawa
• 通讯作者: Yukio Yuzawa

LDL cholesterol performance of beta quantification reference measurement procedure.

• DOI: 10.1016/j.cca.2014.02.018
• 发表时间: 2014-04-20
• 期刊: Clinica chimica acta; international journal of clinical chemistry
• 作者: Nakamura M;Kayamori Y;Iso H;Kitamura A;Kiyama M;Koyama I;Nishimura K;Nakai M;Noda H;Dasti M;Vesper HW;Miyamoto Y
• 通讯作者: Miyamoto Y

Haptoglobin phenotype predicts cerebral vasospasm and clinical deterioration after aneurysmal subarachnoid hemorrhage. Journal of stroke and cerebrovascular diseases

触珠蛋白表型可预测动脉瘤性蛛网膜下腔出血后的脑血管痉挛和临床恶化。

• 发表时间: 2013
• 期刊: the official journal of National Stroke Association
• 作者: Ohnishi H;Iihara K;Kaku Y;Yamauchi K;Fukuda K;Nishimura K;Nakai M;Satow T;Nakajima N;Ikegawa M
• 通讯作者: Ikegawa M

Treated and untreated hypertension, hospitalization, and medical expenditure: an epidemiological study in 314 622 beneficiaries of the medical insurance system in Japan

• DOI: 10.1097/hjh.0b013e32835f5747
• 发表时间: 2013-05-01
• 期刊: JOURNAL OF HYPERTENSION
• 影响因子: 4.9
• 作者: Nakamura, Koshi;Miura, Katsuyuki;Okayama, Akira
• 通讯作者: Okayama, Akira

BMIによる高血圧発症リスクの検討ー吹田研究

根据 BMI 检查患高血压的风险 - Suita 研究

• 发表时间: 2013
• 作者: 中井陸運;西村邦宏;渡邉至;小久保喜弘;岡村智教;宮本恵宏
• 通讯作者: 宮本恵宏