Interaction of cognitive function and glucose metabolism -angiotenisn IV and IRAP system as a new therapeutic target-

我之前研究的澳大利亚实验室克隆了胰岛素调节氨基肽酶（IRAP）作为血管紧张素IV的受体，肾素-血管紧张素系统的亚组分。它是锌依赖性膜氨基肽酶家族的一员，主要位于海马，在GLUT4的膜转运中起重要作用。我们报道了另一种亚成分，血管紧张素（1-7）通过增加MEF1和GLUT4的产生来改善葡萄糖耐受不良。我们计划将血管紧张素IV和IRAP作为治疗认知障碍的新靶点，使用来自澳大利亚实验室的IRAP敲除小鼠的淀粉样蛋白β 1-40心室灌注模型。该模型的认知功能太不稳定，无法评估血管紧张素IV和IRAP对认知障碍的作用，我们现在计划用IRAP和APP制作双敲除小鼠。

The Australian laboratory which I investigated before cloned the insulin-regulated aminopeptidase (IRAP) as a receptor for angiotensin IV, sub-component of renin-angiotensin system. It is a member of the family of zinc- dependent membrane aminopeptidases, which is mainly located in hippocampus and plays an important role for translocation to membrane of GLUT4. We reported another sub-component, angiotensin (1-7) improved glucose intolerance via increased MEF1 and GLUT4 production. We planned angiotensin IV and IRAP as a new therapeutic target for cognitive impairment using amyloid beta 1-40 intra-ventricular infusion model with IRAP knockout mice donated from the Australian laboratory. The cognitive function of this model is too unstable to evaluate angiotensin IV and IRAP function for cognitive impairment, we are now planning to make double knockout mice with IRAP and APP.