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The role of single nucleotide polymorphism of COX-2 gene in the progression of chronic gastritis

The role of single nucleotide polymorphism of COX-2 gene in the progression of chronic gastritis
COX-2基因单核苷酸多态性在慢性胃炎进展中的作用
批准号:
23590927
负责人:
SAKAMOTO Choitsu
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We investigated to see how single nucleotide polymorphism (SNP) of cyclooxygenase(COX)-2 and IL-1 beta genes is involved in the progression of Helicobacter pylori(Hp) gastritis to strophic gastritis, comparing SNP (COX-2SNP rs689466, IL-1 betaSNP rs16944) and atrophic scores determined by histrolgy. Activity, inflammation, atrophy and intestinal metaplasma in Hp-gastritis mucosa were histologideally scored as 0-3 according to Updated Sydney system. 1L-1betaSNP-511T/T was shown to be correlated with the progression of strophic gastritis as previously reported. However, COX-2 gene SNP -1195 was not found to be correlated with strophic gastritis in the present study.
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CD44陽性胃癌幹細胞のCOX-2発現の解析
CD44阳性胃癌干细胞中COX-2表达分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [山脇博士, 二神生爾, 河越哲郎, その他(計11名)]
通讯作者: その他(計11名)
消化管粘膜傷害とシクロオキシゲナーゼ(COX)-2の役割
胃肠粘膜损伤及环氧合酶(COX)-2的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [山脇博士, 二神生爾, 河越哲郎, その他(計11名), 坂本長逸]
通讯作者: 坂本長逸
Heregulin, an agonist of erb3 or erb4, expression linked to a COX-2-PEG2 pathway in fibroblasts possibly plays a role in ulcer repair process in humans
Heregulin 是 erb3 或 erb4 的激动剂,其表达与成纤维细胞中的 COX-2-PEG2 途径相关,可能在人类溃疡修复过程中发挥作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [名児耶浩幸, 二神生爾, 坂本長逸, Sakamoto C]
通讯作者: Sakamoto C
H. pylori陽性胃炎患者におけるCOX-2のSNPを用いた除菌後ハイリスク群の絞り込み
H. pylori 阳性胃炎患者使用 COX-2 SNP 根除后缩小高危人群范围
DOI: --
发表时间: 2014
期刊:
影响因子: --
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8
    The role of COX-2 and the effect of COX-2 antagonist on the progression of intestinal metaplasia and gastric cancer
    • 批准号:
      18590704
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.49万
    • 财政年份:
      2006
    • 负责人:
      SAKAMOTO Choitsu
    • 依托单位:
    The role of COX-2-induced heregulin expression and erbB2 phosphorylation in gastrointestinal tract
    • 批准号:
      16590641
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.56万
    • 财政年份:
      2004
    • 负责人:
      SAKAMOTO Choitsu
    • 依托单位:
    Role of tomoregulin, a novel EGF like molecule containing follistatin modules, in the gastrointestinal mucosa
    • 批准号:
      12470130
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.15万
    • 财政年份:
      2000
    • 负责人:
      SAKAMOTO Choitsu
    • 依托单位:
    Role of a novel EGF-like molecule containing follistatin modules in the gastrointestinal mucosa
    • 批准号:
      09470139
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.51万
    • 财政年份:
      1997
    • 负责人:
      SAKAMOTO Choitsu
    • 依托单位:
    海外基金