Evaluation of spacial heterogeneous distribution of ventricular repolarization and arrhythmic risk by the body surface standard electrocardiogram

体表标准心电图评价心室复极空间异质分布及心律失常风险

• 批准号: 23591032
• 负责人: IZUMI Daisuke
• 金额: $ 3.16万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591032/
• 关键词: QT延長; T波; 不整脈; 再分極; 多形性心室頻拍; 多型性心室頻拍

Fatal ventricular tachyarrhythmias often originate from enlargement of ventricular transmural dispersion of repolarization (TDR). Using canine model which showed spacial heterogeneous distribution of ventricular repolarization, we studied the relationship between the interval of the peak-to-end of the T wave (Tp-e) in ECG and the 3-dimensional repolarization heterogeneity. Tp-e in the limb leads expresses total distribution of repolarization in the left ventricle (LV). The proportion of variance of TDR in each LV region for Tp-e on V2-4 were higher in the anterior rather than in the lateral region, while those on V5-6 were higher in the lateral or midventricular/apical region rather than in the anterior or basal region. The precordial Tp-e seemed to express a certain degree of TDR at near and vertical ventricular wall. These results elucidated the electrophysiological background of the T wave and showed the alternative method of the discrimination of the fatal arrhythmic risk.

致死性室性快速心律失常常起源于心室跨壁复极离散度（TDR）增大。本文利用犬心室复极空间不均匀性模型，研究心电图T波峰末间期（Tp-e）与心室复极三维不均匀性的关系。肢体导联中的TP-e表示左心室（LV）中复极的总分布。V2-4时各LV区域TDR的Tp-e变异比例在前部高于侧部，而V5-6时在侧部或室中/心尖部高于前部或基底部。心前区Tp-e在近垂直室壁处有一定程度的TDR表达。这些结果阐明了T波的电生理学背景，并为致死性心脏病风险的鉴别提供了一种新的方法。

项目成果

Correlation between Spatial Repolarization and Peak-to-end of the T Wave on Transmural Left Ventricular and Body Surface ECG

透壁左心室和体表心电图空间复极与T波峰-端的相关性

• 发表时间: 2011
• 作者: Daisuke Izumi;Masaomi Chinushi;Kenichi Iijima;Kanae Hasegawa;Akinori Sato;Hiroshi Furushima;Yoshifusa Aizawa
• 通讯作者: Yoshifusa Aizawa

Correlation between the T Peak-to-End Interval (Tp-e) on the Surface Precordial Leads ECG and the Intracardiac Spacial LV Repolarization Distribution

表面心前导联心电图 T 峰至端间期 (Tp-e) 与心内空间 LV 复极分布之间的相关性

• 作者: 伊藤哲也;川茂幸;Sato Akinori;Daisuke Izumi
• 通讯作者: Daisuke Izumi

Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead.

由于同径向左心室双极导线的环和尖端导体随后断裂，导致心脏再同步治疗故障。

• 发表时间: 2013
• 期刊: Intern Med.
• 作者: Sato A;Chinushi M;Izumi D;Furushima H;Minamino T.
• 通讯作者: Minamino T.

Effects of primary prevention ICD therapy for sudden cardiac death in patients with old myocardial infarction or idiopathic dilated cardiomyopathy

陈旧性心肌梗死或特发性扩张型心肌病一级预防ICD治疗心源性猝死的效果

• 发表时间: 2012
• 作者: Daisuke Izumi;Masaomi Chinushi;Hiroshi Furushima;Kenichi Iijima;Akinori Sato;Hiroshi Watanabe;Tohru Minamino
• 通讯作者: Tohru Minamino

Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead

由于同径向左心室双极导线的环和尖端导体随后断裂而导致心脏再同步治疗故障

• 发表时间: 2013
• 期刊: Intern Med
• 作者: Sato A;Chinushi M;Izumi D;Furushima H;Minamino T.
• 通讯作者: Minamino T.