Roles of Th9 cells in the development of allergic glanulomatous angitis and asthma

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Recent studies have shown that prplonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling. However, roles of IL-25, which promotes Th2-type inflammation, in the development of pulmonary arterial remodeling remain unknown. In this study, we evaluated the role of IL-25 in the development of pulmonary arterial remodeling. Repeated OVA inhalation induced pulmonary arterial wall thickening and the expression of IL-25 and RELMa mRNA in the lung in OVA-sensitized mice. Injection of neutralizing anti-IL-25 antibody inhibited OVA-induced pulmonary arterial wall thickening and RELMa expression in the lung. CC10 IL-25 mice but not CC10 IL-25 NKT-/- mice spontaneously developed pulmonary arterial wall thickening and RELMa expression in the lung at 6 months of age. These results shows that prolonged expression of IL-25 in the lung induces pulmonary arterial wall thickening by NKT cell-dependent mechanisms.