microRNA分析在肺癌诊断和治疗中的应用-猫眼课题宝

microRNA分析在肺癌诊断和治疗中的应用

批准号：

23591144

负责人：

KONDO Masashi

金额：

$3.33万

依托单位：

Nagoya University

依托单位国家：

日本

项目类别：

Grant-in-Aid for Scientific Research (C)

财政年份：

2011

资助国家：

日本

项目状态：

已结题

起止时间：

2011 至 2013

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591144/

关键词：

マイクロリボ核酸肺癌

项目摘要

项目成果

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中文摘要

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英文摘要

MicroRNA-127 (miR-127) is located in 14q32 region and the deletion in this region has been reported in lung cancer as well as gastric cancer and hepatocellular carcinoma. The reduced expressions of miR-127 were observed in most of lung cancer cell lines, compared the immortalized normal human bronchial epithelial cell by real time PCR method with Taqman microRNA assay. The overexpression of miR-127 in two lung cancer cell lines, leaded to tumor growth inhibition. Moreover, mRNA microarray analysis of H1975 cancer cell lines after transfection of miR-127 mimic indicated the candidate target genes of miR-127. These results suggested that miR-127 have tumor suppressive effect in non-small-cell lung cancer.

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会议论文

The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.

DOI： 10.1002/ijc.27598

发表时间： 2012-12-15

期刊：

INTERNATIONAL JOURNAL OF CANCER

影响因子： 6.4

作者：

[Elshazley, Momen, Sato, Mitsuo, Hase, Tetsunari, Yamashita, Ryo, Yoshida, Kenya, Toyokuni, Shinya, Ishiguro, Futoshi, Osada, Hirotaka, Sekido, Yoshitaka, Yokoi, Kohei, Usami, Noriyasu, Shames, David S., Kondo, Masashi, Gazdar, Adi F., Minna, John D., Hasegawa, Yoshinori]

通讯作者： Hasegawa, Yoshinori

Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells.

瞬态但不稳定的Zeb1敲低会大大抑制恶性胸膜间皮瘤细胞的生长。

DOI： 10.1245/s10434-011-2142-0

发表时间： 2012-07

期刊：

Annals of surgical oncology

影响因子： 3.7

作者：

[Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y]

通讯作者： Hasegawa Y

GENETIC POLYMORPHISMS OF THE ADENOSINE TRIPHOSPHATE-BINDING CASSETTE TRANSPORTERS(ABCG2, ABCB1) AND GEFITINIB TOXICITY

DOI： 10.18999/nagjms.74.1-2.133

发表时间： 2012-02

期刊：

Nagoya Journal of Medical Science

影响因子： 0.9

作者：

[Mariko Tamura;M. Kondo;Mihoko Horio;M. Ando;H. Saito;Masashi Yamamoto;Y. Horio;Y. Hasegawa]

通讯作者： Mariko Tamura;M. Kondo;Mihoko Horio;M. Ando;H. Saito;Masashi Yamamoto;Y. Horio;Y. Hasegawa

Functional analysis of miR-127 in non-small-cell lung cancer 非小細胞肺癌におけるmiR-127の機能解析

miR-127在非小细胞肺癌中的功能分析 miR-127在非小细胞肺癌中的功能分析