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Functional analysis of cancer stem cell/side population in non-small lung cancer cells

Functional analysis of cancer stem cell/side population in non-small lung cancer cells
非小细胞肺癌细胞中癌症干细胞/旁群的功能分析
批准号：
20590918
负责人：
KONDO Masashi
金额：
$3.08万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590918/
关键词：
EGFR癌幹細胞非小細胞肺癌肺癌癌幹細EGFR遺伝子変異

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中文摘要
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英文摘要
Functional analysis of cancer stem cell is very important to establish the method of early detection and/or effective therapy for the non-small cell lung cancer since stem cells seem to be involved carcinogenesis and the resistance for the chemotherapy. In this study, we try to identify the cell populations that have cancer stem cell property and important molecule related with stem cells. We fund that the formation of sphere in serum free and anchorage-dependent culture condition was promising for the selection of stem cells population, and that epithelial cell adhesion molecule (EpCAM) play the important roll in survival of cancer cells.
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Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells.
DOI： 10.1016/j.canlet.2010.04.008
发表时间： 2010-10-28
期刊： CANCER LETTERS
影响因子： 9.7
作者： [Takeyama, Yoshihiro, Sato, Mitsuo, Horio, Mihoko, Hase, Tetsunari, Yoshida, Kenya, Yokoyama, Toshihiko, Nakashima, Harunori, Hashimoto, Naozumi, Sekido, Yoshitaka, Gazdar, Adi F., Minna, John D., Kondo, Masashi, Hasegawa, Yoshinori]
通讯作者： Hasegawa, Yoshinori
Knockdown of ZEB1, a master EMT inducing gene, suppresses, anchorage-independent cell growth of lung cancer cells
ZEB1（一种主要的 EMT 诱导基因）的敲低可抑制肺癌细胞的贴壁依赖性细胞生长
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Mitsuo Sato , Yoshihiro Takeyama , Mihoko Horio, Tetsunari Hase, Kenya Yoshida1,Harunori Nakashima, Naozumi Hashimoto, Yoshitaka Sekido, Masashi Kondo, Yoshinori Hasegawa]
通讯作者： Yoshinori Hasegawa
Phase II study of carboplatin and gemcitabine as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: a report from the Central Japan Lung Study Group, CJLSG 0503 trial
DOI： 10.1007/s10147-010-0118-x
发表时间： 2010-12-01
期刊： INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
影响因子： 3.3
作者： [Usami, Noriyasu, Yokoi, Kohei, Shimokata, Kaoru]
通讯作者： Shimokata, Kaoru
Prospective evaluation of pharmacokinetically guided dosing of carboplatin in Japanese patients with cancer
DOI： 10.1111/j.1349-7006.2010.01729.x
发表时间： 2010-12-01
期刊： CANCER SCIENCE
影响因子： 5.7
作者： [Shimokata, Tomoya, Ando, Yuichi, Hasegawa, Yoshinori]
通讯作者： Hasegawa, Yoshinori
共 12 条
    A study of Arthur Lyon Bowley: an inheritance and development of Alfred Marshall
    • 批准号：
      24530216
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.5万
    • 财政年份：
      2012
    • 负责人：
      KONDO Masashi
    • 依托单位：
      Osaka Prefecture University
    Analysis of microRNA for the diagnosis and treatment of lung cancer
    • 批准号：
      23591144
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.33万
    • 财政年份：
      2011
    • 负责人：
      KONDO Masashi
    • 依托单位：
      Nagoya University
    The study of statistical methodology on Bowley and Layton : The development and application of Marshall's economics
    • 批准号：
      21530184
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.41万
    • 财政年份：
      2009
    • 负责人：
      KONDO Masashi
    • 依托单位：
      Osaka Prefecture University
    Walter Layton on the Cambridge School
    • 批准号：
      19530171
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $0.92万
    • 财政年份：
      2007
    • 负责人：
      KONDO Masashi
    • 依托单位：
      Osaka Prefecture University
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