Analysis on the renoprotective effects and clinical significance of endogenous Vasohibin family in chronic kidney disease

内源性血管抑制素家族对慢性肾脏病的肾脏保护作用及临床意义分析

• 批准号: 23591193
• 负责人: MAESHIMA YOHEI
• 金额: $ 3.33万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591193/
• 关键词: 慢性腎臓病; 血管新生; 糖尿病性腎症; Vasohibin-1; 尿細管間質障害; 線維化; 血管内皮細胞; 炎症

The population of CKD patients in Japan is estimated as 13.3 million people. CKD is a risk factor of end-stage renal disease and cardiovascular disorders. Here, we examined the functional role of Vasohibin-1, a negative feedback regulator of angiogenesis, in CKD. Diabetic nephropathy, tubulointerstitial injuries induced by unilateral ureteral obstruction and acute kidney injury were exacerbated in the Vasofibin-1+/-- mice compared with the wild-type mice. Renal Vasohibin-1 expression was associated with crescentic lesions and interstitial inflammation in CKD patients. Elevated plasma/urinary levels of Vasohibin-1 predicted progressive renal functional deterioration in CKD patients. These results suggest the potential renoprotective effects of Vasohibin-1 and its potential as a novel biomarker in CKD.

日本的CKD患者人口估计为1,330万人。 CKD是终末期肾脏疾病和心血管疾病的危险因素。 在这里，我们研究了CKD中血管生成的负反馈调节剂血管丁质-1的功能作用。 与野生型小鼠相比，在血管表皮蛋白-1+/ - 小鼠中，单侧输尿管阻塞和急性肾脏损伤引起的糖尿病性肾病，肾小管间隙损伤加剧了。 CKD患者的肾血管肽-1表达与新月形病变和间质性炎症有关。血浆升高的血浆/尿液水平的血管丁质-1预测CKD患者的进行性肾功能恶化。这些结果表明，血管丁质1及其作为CKD中新型生物标志物的潜在肾脏保护作用。

项目成果

Urinary levels of prostanoid metabolites predict for acute kidney injury in adult Japanese heterogenous ICU patients

尿前列腺素代谢物水平可预测日本异质 ICU 成年患者的急性肾损伤

• 发表时间: 2012
• 作者: Haruyo Ujike;Yohei Maeshima;Masaru Kinomura; Hirofumi Makino;et al.
• 通讯作者: et al.

糖尿病性腎症における血管新生制御因子Vasohibin-1によるnephrin発現回復効果の基礎的検討

血管生成调节因子 Vasohibin-1 对糖尿病肾病去氧肾上腺素表达恢复作用的基础研究

• 发表时间: 2011
• 作者: 斎藤大輔;前島洋平;雛元紀和;綿谷博雪;山崎浩子;木野村賢;喜多村真治;杉山 斉;園田 光;佐藤靖史;槇野博史
• 通讯作者: 槇野博史

腎疾患・透析最新の治療2011-2013

2011-2013 年肾脏疾病和透析的最新治疗方法

• 发表时间: 2011
• 作者: 前島洋平;槇野博史
• 通讯作者: 槇野博史

Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.

• DOI: 10.1074/jbc.m113.451054
• 发表时间: 2013-06-28
• 期刊: The Journal of biological chemistry
• 作者: Matsuda M;Tamura K;Wakui H;Maeda A;Ohsawa M;Kanaoka T;Azushima K;Uneda K;Haku S;Tsurumi-Ikeya Y;Toya Y;Maeshima Y;Yamashita A;Umemura S
• 通讯作者: Umemura S

Novel Prostacyclin Analog ONO-1301 (SR-ONO) Ameliorates AKI in a Rat Experimental Contrast-Induced Nephropathy Model

新型前列环素类似物 ONO-1301 (SR-ONO) 可改善大鼠实验性对比诱发肾病模型中的 AKI

• 发表时间: 2013
• 作者: Ujike H;Maeshima Y;Hinamoto N;Watatani H;Masuda K;Tanabe K;Sugiyama H;Sakai Y;Makino H
• 通讯作者: Makino H