Analysis of innate immune cells in inflammatory demyelinating diseases of the central nervous system
Analysis of innate immune cells in inflammatory demyelinating diseases of the central nervous system
批准号:
23591236
负责人:
KAWACHI Izumi
金额:
$3.49万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Neuromyelitis optica (NMO) and multiple sclerosis are the two main autoimmune, inflammatory and demyelinating syndromes of the central nervous system. The discovery of NMO immunoglobulin G autoantibody, which targets the water channel aquaporin-4 (AQP4) and is a specific marker of NMO, should revolutionize understanding of pathogenesis in the two diseases. Not only IL-17/IFN-gamma-producing cells, but also innate immune cells including neutrophils, antigen-presenting cells, plasma cells and plasmablasts were evident in NMO lesions. These data suggest that unique dynamics of innate immune cells might be present in NMO in situ.
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Clinical Profiles of Elderly Patients with ADEM in A Japanese Cohort
日本队列老年 ADEM 患者的临床概况
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Hokari M, Saji E, Yokoseki A, Arakawa M, Nishizawa M, Kawachi I]
通讯作者:
Kawachi I
Humoral and cellular immune responses in neuromyelitis optica.
视神经脊髓炎的体液和细胞免疫反应。
DOI:
--
发表时间:
2010
期刊:
Rinsho Shinkeigaku 50
影响因子:
--
作者:
[矢島隆二, 池内健, 春日健作, 徳武孝允, 西澤正豊, 河内泉]
通讯作者:
河内泉
DOI:
10.1186/1471-2377-14-3
发表时间:
2014-01-06
期刊:
BMC neurology
影响因子:
2.6
作者:
[Niino M, Mifune N, Kohriyama T, Mori M, Ohashi T, Kawachi I, Shimizu Y, Fukaura H, Nakashima I, Kusunoki S, Miyamoto K, Yoshida K, Kanda T, Nomura K, Yamamura T, Yoshii F, Kira J, Nakane S, Yokoyama K, Matsui M, Miyazaki Y, Kikuchi S]
通讯作者:
Kikuchi S
多発性硬化症・視神経脊髄炎における認知機能障害.多発性硬化症の新展開
多发性硬化症和视神经脊髓炎的认知功能障碍。多发性硬化症的新进展
DOI:
--
发表时间:
2013
期刊:
脳21
影响因子:
--
作者:
[市川弥生子, 西垣昌和, 今井 靖, 平田恭信, 辻 省次, 後藤 順, 河内泉,西澤正豊]
通讯作者:
河内泉,西澤正豊
Diagnostic dilemma of Japanese patients with AQP4 antibody
日本AQP4抗体患者的诊断困境
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kawachi I, Yanagawa K, Saji E, Yokoseki A, Hokari M, Nishizawa M]
通讯作者:
Nishizawa M
共 37 条
Dynamics of innate immune cells per se in autoimmune CNS disorders
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批准号:17K09776
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2017
-
负责人:KAWACHI Izumi
-
依托单位:
Analysis of granulocytes in inflammatory autoimmune disorders of the central nervous system
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批准号:26461289
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2014
-
负责人:KAWACHI Izumi
-
依托单位:
Possible pathomechanism of multiple sclerosis from the perspective of abnormal mucosal immune responses
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批准号:20590991
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2008
-
负责人:KAWACHI Izumi
-
依托单位:
海外基金