Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis.
Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis.
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DOI：
10.1186/1471-2377-14-3
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发表时间：
2014-01-06
期刊：
影响因子：
2.6
通讯作者：
Kikuchi S
中科院分区：
文献类型：
--
作者：
Niino M;Mifune N;Kohriyama T;Mori M;Ohashi T;Kawachi I;Shimizu Y;Fukaura H;Nakashima I;Kusunoki S;Miyamoto K;Yoshida K;Kanda T;Nomura K;Yamamura T;Yoshii F;Kira J;Nakane S;Yokoyama K;Matsui M;Miyazaki Y;Kikuchi S
认知功能障碍可能影响多发性硬化症（MS）患者的生活质量，认知功能可能与抑郁和疲劳等多种因素相关。本研究旨在评价日本MS患者的认知功能以及认知功能与冷漠、疲劳和抑郁之间的相关性。在184名日本MS患者和163名年龄、性别和教育程度相匹配的健康对照者中进行了简短的可重复神经心理学测试（BRB-N）。冷漠量表（AS），疲劳问卷（FQ）和贝克抑郁量表第二版（BDI-II）分别用于评估冷漠，疲劳和抑郁。学生t检验用于比较MS患者和健康对照。两个因素之间的相关性进行了评估，使用皮尔逊相关性检验，和多元回归分析，以评估有多少每个因素影响的BRB-N评分。在所有BRB-N测验中，MS患者的得分均显著低于对照组，并且在BRB-N的9个测验中，符号数字模态测验的效应量最高。MS患者的AS（p < 0.001）、FQ（p < 0.0001）和BDI-II（p < 0.0001）评分高于对照组。在MS患者中，大多数BRB-N测试的分数与AS和BDI-II的分数相关;然而，BRB-N测试的分数与FQ的分数之间几乎没有相关性。认知功能受损，特别是信息处理速度，认知功能下降与冷漠和抑郁症在日本MS患者。尽管认知变量和抑郁症/冷漠之间的关联，认知功能受损超出抑郁症和冷漠的影响。而主观疲劳与认知功能损害无关。总之，这表明需要不同的治疗方法来改善MS患者的主观疲劳和认知，从而改善生活质量。
Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression. The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student’s t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score. In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p < 0.001), FQ (p < 0.0001), and BDI-II (p < 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ. Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.
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影响因子：
2.8
作者：
Abe, K;Takanashi, M;Yanagihara, T
通讯作者：
Yanagihara, T
影响因子：
2.6
作者：
Middleton, Laura S.;Denney, Douglas R.;Parmenter, Brett
通讯作者：
Parmenter, Brett
DOI：
10.1177/135245850100700409
发表时间：
2001-08-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Boringa, JB;Lazeron, RHC;Polman, CH
通讯作者：
Polman, CH
影响因子：
5.8
作者：
Bailey, A.;Channon, S.;Beaumont, J. G.
通讯作者：
Beaumont, J. G.
影响因子：
5.8
作者：
Morrow, S. A.;Weinstock-Guttman, B.;Benedict, R. H. B.
通讯作者：
Benedict, R. H. B.