Influence of chronic kidney disease on carotid atherosclerosis, stroke features, and outcomes of thrombolysis for acute stroke

为了确定慢性肾脏疾病（CKD）和脑血管疾病之间的相关性，换句话说，肾脏相互作用，进行了以下研究。(1)在Suita研究（一项涉及日本城市居民的流行病学研究）中，CKD与颈动脉粥样硬化的相关性不大，但CKD与高血压受试者的颈动脉粥样硬化独立相关。(2)在急性脑出血患者中，收缩压过度降低与急性肾功能恶化相关。肾功能恶化与不良临床结局相关。(3)在多中心研究中，肾功能不全与rt-PA治疗的缺血性卒中患者和脑出血患者的不良结局独立相关。(4)部分基于当前研究结果，完成了关于肾脏-肾脏相互作用的英文综述。

To determine associations between chronic kidney disease (CKD) and cerebrovascular diseases, in the other words cerebro-renal interaction, the following studies were performed. (1) In the Suita Study, an epidemiological study involving Japanese urban residents, the association of CKD with carotid atherosclerosis was modest, but CKD was independently associated with carotid atherosclerosis in hypertensive subjects. (2) In acute intracerebral hemorrhage patients, excessive reduction of systolic blood pressure was associated with acute worsening renal function. Worsening renal function was related to unfavorable clinical outcome. (3) In the multicenter study, renal dysfunction was independently associated with unfavorable outcomes in rt-PA-treated ischemic stroke patients and those in intracerebral hemorrhage patients. (4) An English review on cerebro-renal interaction was completed partly based on the current study results.