Influence of chronic kidney disease on carotid atherosclerosis, stroke features, and outcomes of thrombolysis for acute stroke

慢性肾脏病对颈动脉粥样硬化、卒中特征和急性卒中溶栓结果的影响

• 批准号: 23591288
• 负责人: TOYODA Kazunori
• 金额: $ 3.08万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591288/
• 关键词: 脳血管障害; 慢性腎臓病; 頸動脈硬化; 脳腎連関; 脳出血; 脳梗塞; rt-PA静注療法

To determine associations between chronic kidney disease (CKD) and cerebrovascular diseases, in the other words cerebro-renal interaction, the following studies were performed. (1) In the Suita Study, an epidemiological study involving Japanese urban residents, the association of CKD with carotid atherosclerosis was modest, but CKD was independently associated with carotid atherosclerosis in hypertensive subjects. (2) In acute intracerebral hemorrhage patients, excessive reduction of systolic blood pressure was associated with acute worsening renal function. Worsening renal function was related to unfavorable clinical outcome. (3) In the multicenter study, renal dysfunction was independently associated with unfavorable outcomes in rt-PA-treated ischemic stroke patients and those in intracerebral hemorrhage patients. (4) An English review on cerebro-renal interaction was completed partly based on the current study results.

为了确定慢性肾脏疾病（CKD）和脑血管疾病之间的关系，换句话说，脑-肾相互作用，进行了以下研究。(1)在日本城市居民的流行病学研究Suita Study中，CKD与颈动脉粥样硬化的相关性不大，但在高血压受试者中，CKD与颈动脉粥样硬化独立相关。(2)急性脑出血患者收缩压过度降低与肾功能急性恶化相关。肾功能恶化与不良临床结果有关。(3)在多中心研究中，在rt- pa治疗的缺血性脑卒中患者和脑出血患者中，肾功能不全与不良结局独立相关。(4)基于目前的研究结果，完成了一篇关于脑肾相互作用的英文综述。

项目成果

Epidemiology and registry studies of stroke in Japan.

• DOI: 10.5853/jos.2013.15.1.21
• 发表时间: 2013-01
• 期刊: Journal of stroke
• 影响因子: 8.2
• 作者: Toyoda K

Antithrombotic therapy for pregnant women

孕妇的抗血栓治疗

• 发表时间: 2013
• 期刊: Neurologia Medico-chirurgica
• 影响因子: 1.9
• 作者: Hokkoku K;Sonoo M;Higashihara M;et al.;Toyoda K
• 通讯作者: Toyoda K

Stroke features & outcomes in CKD patients

脑卒中特征

• 发表时间: 2013
• 作者: Toyoda K

Intracerebral hemorrhage during oral antithrombotic therapy

口服抗栓治疗期间发生脑出血

• 发表时间: 2012
• 作者: Mitsueda-Ono T;Ikeda A;Inouchi M;Takaya S;Matsumoto R;Hanakawa T;Sawamoto N;Mikuni N;Fukuyama H;Takahashi R;Toyoda K
• 通讯作者: Toyoda K

今日の治療指針2012年版

今日治疗指南2012年版

• 发表时间: 2013
• 作者: 和田則仁;古川俊治
• 通讯作者: 古川俊治