Influence of chronic kidney disease on carotid atherosclerosis, stroke features, and outcomes of thrombolysis for acute stroke

为了确定慢性肾脏疾病(CKD)和脑血管疾病之间的关系，换句话说，脑-肾相互作用，进行了以下研究。(1)在一项涉及日本城市居民的流行病学研究Suita研究中，慢性肾脏病与颈动脉粥样硬化的关联不大，但在高血压患者中，慢性肾脏病与颈动脉粥样硬化独立相关。(2)在急性脑出血患者中，收缩压过低与急性肾功能恶化有关。肾功能恶化与不良的临床结局有关。(3)在多中心研究中，在接受rt-PA治疗的缺血性中风患者和脑出血患者中，肾功能障碍与不良预后独立相关。(4)部分基于目前的研究结果完成了一篇关于脑-肾相互作用的英文综述。

To determine associations between chronic kidney disease (CKD) and cerebrovascular diseases, in the other words cerebro-renal interaction, the following studies were performed. (1) In the Suita Study, an epidemiological study involving Japanese urban residents, the association of CKD with carotid atherosclerosis was modest, but CKD was independently associated with carotid atherosclerosis in hypertensive subjects. (2) In acute intracerebral hemorrhage patients, excessive reduction of systolic blood pressure was associated with acute worsening renal function. Worsening renal function was related to unfavorable clinical outcome. (3) In the multicenter study, renal dysfunction was independently associated with unfavorable outcomes in rt-PA-treated ischemic stroke patients and those in intracerebral hemorrhage patients. (4) An English review on cerebro-renal interaction was completed partly based on the current study results.