Elucidation of the mechanism of metabolic syndrome due to the gene targeting analysis of the causative gene

[目的和方法]通过对KAT-1基因的打靶分析，探讨代谢综合征的起源及其生理功能。[结果与结论]与SHR一样，Kat-1基因敲除小鼠在正常饮食和12周高盐饮食中血压和心率显著升高，在高盐饮食中24小时尿儿茶酚胺分泌量增加，血浆醛固酮浓度升高，肾素活性降低，正常饮食胰岛素耐量试验显示空腹血糖水平显著升高，胰岛素抵抗增强。随着活动量的增加，高脂饮食中体重、脂肪组织重量的增加率呈下降趋势。提示KAT-1可能成为代谢综合征治疗的新靶点。

[Purpose and methods] Through the gene targeting analysis of KAT-1, I explore the origin of metabolic syndrome and its physiological function. [Results and conclusions] As with the SHR, KAT-1 knockout mice exhibited an increase in blood pressure and heart rate significant in a normal diet and 12 weeks high salt diet, exhibited enhanced catecholamine secretion of 24-hour urine in high salt diet, showed an increase in plasma aldosterone concentration and a decreased in renin activity, showed a significant increase in fasting blood glucose levels and the enhancement of insulin resistance by insulin tolerance test in normal diet. Along with the increase in activity, and showed a decrease in the rate of increase in body weight, adipose tissue weight in the high-fat diet. It was strongly suggested that KAT-1 is a potential new therapeutic targets for metabolic syndrome.