Analysis of candidate gene deficient mice cause insulin resistance in Spontaneously Hypertensive Rats

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1) Normal delivery, normal growth, and null expression of mRNA and protein in each organization of KAT-1 knockout mouse have been confirmed. KAT-1 knockout mouse demonstrates 2) significant increase of blood pressure under the normal chow, more increase of blood pressure under 12 weeks high salt diet by tail-cuff and telemetry system, 3) the rise of 24-hour urine catecholamine secretion under high salt diet, 4) significant increase of fast blood glucose, the rise of insulin resistance by insulin tolerance test under normal chow, 5) the decrease of the fat pat weight under high fat diet accompanied with increase in activity level.