Clarification of pathogenetic mechanisms of type 1 diabetes and its adaptation to prediction and prevention

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In order to examine the clinical significance of ZnT8 autoantibodies in type 1 diabetes, six ZnT8/ZnT3 chimeric cDNA were created and ZnT8 autoantibody epitopes were analyzed. As a result, the carboxy-terminal 10 amino acid residues in ZnT8 contribute to conformational epitope(s) that is associated with acute-onset and younger-onset type 1 diabetes.Although prevalence of ZnT8 autoantibodies was higherin acute-onset or younger-onset patients at disease onset, it persisted in adult-onsetpatients.Furthermore, we have evaluated a newly developed ZnT8 autoantibody ELISA.